Al-Darsani Zeinah, Jacobs David R, Bryan R Nick, Launer Lenore J, Steffen Lyn M, Yaffe Kristine, Shikany James M, Odegaard Andrew O
Department of Epidemiology and Biostatistics, University of California, Irvine, Irvine, CA, USA.
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Nutr Healthy Aging. 2023 Aug 4;8(1):109-121. doi: 10.3233/NHA-220192. eCollection 2023.
The Mediterranean diet (MedDiet) has been linked with better cognitive function and brain integrity.
To examine the association of modified Mediterranean diet (mMedDiet) scores from early through middle adulthood in relation to volumetric and microstructural midlife MRI brain measures. Assess the association of mMedDiet and brain measures with four cognitive domains. If variables are correlated, determine if brain measures mediate the relationship between mMedDiet and cognition.
618 participants (mean age 25.4±3.5 at year 0) of the Coronary Artery Risk Development in Young Adults (CARDIA) study were included. Cumulative average mMedDiet scores were calculated by averaging scores from years 0, 7, and 20. MRI scans were obtained at years 25 and 30. General linear models were used to examine the association between mMedDiet and brain measures.
Higher cumulative average mMedDiet scores were associated with better microstructural white matter (WM) integrity measured by fractional anisotropy (FA) at years 25 and 30 (all p <0.05). Higher mMedDiet scores at year 7 were associated with higher WM FA at year 25 (β= 0.003, p = 0.03). Higher mMedDiet scores at year 20 associated with higher WM FA at years 25 (β= 0.0005, p = 0.002) and 30 (β= 0.0003, p = 0.02). mMedDiet scores were not associated with brain volumes. Higher mMedDiet scores and WM FA were both correlated with better executive function, processing speed, and global cognition (all p <0.05). WM FA did not mediate the association between mMedDiet scores and cognition.
mMedDiet scores may be associated with microstructural WM integrity at midlife.
地中海饮食（MedDiet）与更好的认知功能和大脑完整性有关。
研究从成年早期到中年期的改良地中海饮食（mMedDiet）得分与中年期MRI脑容量和微观结构测量值之间的关联。评估mMedDiet与四个认知领域的脑测量值之间的关联。如果变量相关，确定脑测量值是否介导了mMedDiet与认知之间的关系。
纳入了618名年轻成年人冠状动脉风险发展（CARDIA）研究的参与者（第0年时平均年龄25.4±3.5岁）。通过对第0年、第7年和第20年的得分进行平均来计算累积平均mMedDiet得分。在第25年和第30年进行MRI扫描。使用一般线性模型来研究mMedDiet与脑测量值之间的关联。
较高的累积平均mMedDiet得分与第25年和第30年通过分数各向异性（FA）测量的更好的微观结构白质（WM）完整性相关（所有p<0.05）。第7年较高的mMedDiet得分与第25年较高的WM FA相关（β=0.003，p=0.03）。第20年较高的mMedDiet得分与第25年（β=0.0005，p=0.002）和第30年（β=0.0003，p=0.02）较高的WM FA相关。mMedDiet得分与脑容量无关。较高的mMedDiet得分和WM FA均与更好的执行功能、处理速度和整体认知相关（所有p<0.05）。WM FA并未介导mMedDiet得分与认知之间的关联。
mMedDiet得分可能与中年期微观结构WM完整性有关。
