Division of Toxicology, Department of Comparative Bioscience, Faculty of Veterinary Medicine, University of Tehran, Qareeb St, Azadi Av., P.O.Box: 14155-6453, Tehran, Iran.
Bull Environ Contam Toxicol. 2023 Nov 28;112(1):2. doi: 10.1007/s00128-023-03824-3.
2,2-Dibromo-3-nitrilopropionamide (DBNPA) is a widely used biocide with potential environmental implications due to its toxicity. This study aimed to investigate the in vivo toxicity of DBNPA in zebrafish (Danio rerio), a model organism in environmental toxicology. Both adult and larval zebrafish were exposed to varying concentrations of DBNPA, and significant morphological changes and mortality rates were observed. The study found that even relatively low concentrations of DBNPA can have detrimental effects on zebrafish embryonic development, and high concentrations resulted in rapid mortality in adult zebrafish and larvae. The LC values calculated from this study were 9.3 ppm for adults and 9.1 ppm for larvae, indicating the high toxicity of DBNPA to these organisms. These findings underscore the potential environmental impact of DBNPA and highlight the need for further research into its effects on aquatic ecosystems.
2,2-二溴-3-氰基丙酰胺（DBNPA）是一种广泛使用的杀菌剂，由于其毒性，可能对环境产生影响。本研究旨在探讨 DBNPA 在斑马鱼（Danio rerio）体内的毒性，斑马鱼是环境毒理学中的一种模式生物。成年和幼鱼斑马鱼都暴露在不同浓度的 DBNPA 中，观察到明显的形态变化和死亡率。研究发现，即使是相对较低的 DBNPA 浓度也会对斑马鱼胚胎发育产生不利影响，而高浓度则导致成年斑马鱼和幼鱼迅速死亡。本研究计算出的 LC 值分别为 9.3ppm 用于成年鱼和 9.1ppm 用于幼鱼，表明 DBNPA 对这些生物具有高毒性。这些发现强调了 DBNPA 的潜在环境影响，并突出了需要进一步研究其对水生生态系统的影响。
