Kaur P, Potten C S
Cell Tissue Kinet. 1986 Nov;19(6):591-9. doi: 10.1111/j.1365-2184.1986.tb00760.x.
The variation in migration rates of cells within the small intestinal epithelium was studied over a 24-hr period at 3-hr intervals (migration of cells was studied independently for the crypts and the villi using the changing distributions of [3H]TdR labelled cells as an indicator of cell migration). Clear changes in the rates of cell movement were observed during a 24-hr period for both crypt and villus epithelium. The rates of cell migration in these two compartments did not correlate well with the exception of samples taken at 18.00 hours. At this time of day there appeared to be no cell movement at all in either crypts or villi. There was not a good correlation between the migration velocity throughout the day and the changes in the number of mitoses. It is proposed that mitotic rates do not directly govern migration rates but that the converse may be true. Further, the lack of correlation between crypt and villus migration rates at any time of day suggest that the mechanisms controlling all movement in these two regions of small intestinal epithelium may be different.
在24小时内，每隔3小时研究一次小肠上皮内细胞的迁移速率变化（使用[³H]TdR标记细胞的变化分布作为细胞迁移的指标，分别独立研究隐窝和绒毛中细胞的迁移）。在24小时内，隐窝和绒毛上皮的细胞移动速率均出现明显变化。除了18:00采集的样本外，这两个区域的细胞迁移速率相关性不佳。在一天中的这个时间，隐窝和绒毛似乎都完全没有细胞移动。全天的迁移速度与有丝分裂数目的变化之间没有良好的相关性。有人提出，有丝分裂速率并不直接控制迁移速率，但反之可能成立。此外，一天中任何时候隐窝和绒毛迁移速率之间缺乏相关性，表明控制小肠上皮这两个区域所有移动的机制可能不同。
