Xing Yuling, Liu Jing, Gao Yu, Zhu Yajun, Zhang Yunjia, Ma Huijuan
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People's Republic of China.
Department of Endocrinology, Affiliated Hospital of Chengde Medical University, Chengde, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Nov 22;16:3795-3805. doi: 10.2147/DMSO.S433493. eCollection 2023.
The triglyceride glucose (TyG) index and TyG-related indicators have been proposed as a marker of insulin resistance. It is unclear which is the best indicator to predict diabetes mellitus (DM) in Chinese. This study aimed to investigate the predictive value of different biomarkers for the incidence of DM.
Between January 2017 and December 2020, 5575 subjects who underwent health examinations in Hebei General Hospital were retrospectively included. The primary endpoint was new onset DM.
During a median follow-up of 3.03 years, 133(2.39%) individuals developed DM. Multivariable cox proportional hazards models revealed that TyG index and TyG-related parameters were positively associated with DM risk. As the interaction analyses showed, there were significant interactions with sex and age levels in relation to DM risk (both P for interaction <0.05). Risk prediction for DM was significantly improved by adding TyG index to the baseline model using conventional diabetic risk factors in predicting DM at follow-up.
This population-based cohort study suggested a causal relationship between TyG index and DM after adjusting for other confounding factors. This independent and significant association was more apparent in females and subjects younger than 65 years. Compared with the TyG-BMI, TyG-WC, TyG-WHtR, the TyG index was a more effective predictor of DM.
甘油三酯葡萄糖（TyG）指数及与TyG相关的指标已被提出作为胰岛素抵抗的标志物。目前尚不清楚在中国哪种指标最能预测糖尿病（DM）。本研究旨在探讨不同生物标志物对DM发病的预测价值。
回顾性纳入2017年1月至2020年12月在河北医科大学第一医院进行健康体检的5575名受试者。主要终点为新发DM。
在中位随访3.03年期间，133例（2.39%）个体发生DM。多变量Cox比例风险模型显示，TyG指数及与TyG相关的参数与DM风险呈正相关。交互分析显示，在DM风险方面，与性别和年龄水平存在显著交互作用（交互作用P值均<0.05）。在随访时预测DM的基线模型中加入TyG指数，可显著改善DM的风险预测。
这项基于人群的队列研究表明，在调整其他混杂因素后，TyG指数与DM之间存在因果关系。这种独立且显著的关联在女性和65岁以下的受试者中更为明显。与TyG-BMI、TyG-WC、TyG-WHtR相比，TyG指数是DM更有效的预测指标。
