Yu Wangqin, Wang Xiaoling, Du Zhongyan, Cheng Wenke
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Pharmacy, Lintong Rehabilitation and Recuperation Centre, Xi'an, China.
Front Nutr. 2024 Oct 23;11:1454880. doi: 10.3389/fnut.2024.1454880. eCollection 2024.
The association between the triglyceride-glucose (TyG) index and its combination with obesity indictors in aortic aneurysm and dissection (AAD) remains unclear. We aimed to investigate the association between TyG and TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR) and AAD risk.
This study included 387,483 baseline participants from the UK Biobank with complete data on TyG, TyG-BMI, TyG-WC and TyG-WHtR. Cox proportional hazard models evaluated the relationship between these four indicators and the risk of AAD occurrence. Restricted cubic spline (RCS) examined the non-linear relationship between these indicators and AAD risk, while receiver operating characteristic (ROC) curves assessed the predictive value of these four indicators for AAD risk.
Over a median follow-up of 13.7 years, 3,041 AAD events were recorded. Multivariate Cox regression analysis indicated that for each standard deviation increase, the risk of AAD occurrence increased by 33% (HR: 1.33, 95%CI: 1.29-1.38), 25% (HR: 1.25, 95%CI: 1.21-1.29), 61% (HR: 1.61, 95%CI: 1.56-1.66) and 44% (HR: 1.44, 95%CI: 1.39-1.49) for TyG, TyG-BMI, TyG-WC and TyG-WHtR, respectively. RCS demonstrated a linear relationship between these indicators and AAD risk, with TyG-WC demonstrating the best performance in predicting AAD occurrence based on ROC curves.
The present study, based on a large prospective cohort design, showed that higher TyG index and its combination with obesity indices were significantly associated with the risk of AAD. Moreover, AFT models further showed that elevation of these indicators significantly advanced the onset of AAD. In addition, RCS analyses demonstrated a linear association between these indicators and the risk of AAD, and the TyG-WC showed higher predictive ability for AAD. These findings emphasize the potential application of the TyG index and its combination with obesity indicators in the early identification of AAD.
甘油三酯-葡萄糖（TyG）指数及其与肥胖指标的组合与主动脉瘤和主动脉夹层（AAD）之间的关联尚不清楚。我们旨在研究TyG与TyG-体重指数（TyG-BMI）、TyG-腰围（TyG-WC）、TyG-腰高比（TyG-WHtR）与AAD风险之间的关联。
本研究纳入了英国生物银行的387,483名基线参与者，他们拥有关于TyG、TyG-BMI、TyG-WC和TyG-WHtR的完整数据。Cox比例风险模型评估了这四个指标与AAD发生风险之间的关系。受限立方样条（RCS）检验了这些指标与AAD风险之间的非线性关系，而受试者工作特征（ROC）曲线评估了这四个指标对AAD风险的预测价值。
在中位随访13.7年期间，记录了3041例AAD事件。多变量Cox回归分析表明，每增加一个标准差，TyG、TyG-BMI、TyG-WC和TyG-WHtR发生AAD的风险分别增加33%（HR：1.33，95%CI：1.29-1.38）、25%（HR：1.25，95%CI：1.21-1.29）、61%（HR：1.61，95%CI：1.56-1.66）和44%（HR：1.44，95%CI：1.39-1.49）。RCS显示这些指标与AAD风险之间存在线性关系，基于ROC曲线，TyG-WC在预测AAD发生方面表现最佳。
本研究基于大型前瞻性队列设计，表明较高的TyG指数及其与肥胖指数的组合与AAD风险显著相关。此外，AFT模型进一步表明，这些指标的升高显著提前了AAD的发病时间。此外，RCS分析表明这些指标与AAD风险之间存在线性关联，且TyG-WC对AAD具有较高的预测能力。这些发现强调了TyG指数及其与肥胖指标的组合在AAD早期识别中的潜在应用。
