Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu, 610041, Sichuan, People's Republic of China.
Department of Audiology and Speech Language Pathology, West China Hospital, Sichuan University, Chengdu, China.
BMC Infect Dis. 2023 Dec 7;23(1):862. doi: 10.1186/s12879-023-08866-w.
The characteristics of otological symptoms in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are lacking. Almost no research has been conducted to explore the emergence of otological symptoms after coronavirus disease 2019 infection. The aims of this study were to investigate the prevalence and specific clinical characteristics of and risk factors for otological symptoms among patients with SARS-CoV-2 infection.
We included two groups to investigate the prevalence and clinical characteristics of otological symptoms among patients with SARS-CoV-2 infection. The first sample (S1) was drawn retrospectively from four communities via questionnaires, and the second sample (S2) from an outpatient clinic.
A total of 189 participants were included in S1 (124 women [65.6%]; mean [standard deviation (SD)] age, 33.66 [13.56] years), and 47 in S2 (25 women [53.2%]; mean [SD] age, 45.28 [14.64] years). The most prevalent otological symptoms in S1 were dizziness (15.9%), tinnitus (7.9%), aural fullness (6.9%), otalgia (5.3%), hearing loss (1.6%), and otopyorrhoea (1.1%). Moreover, for each additional typical symptom of SARS-CoV-2 infection, the risk (odds ratio) of otological symptoms increased by 1.33 (95% confidence interval: 1.10-1.61, p = 0.003). The prevalence of aural fullness was higher in the unvaccinated group than that in the group receiving two or three vaccinations (p = 0.018).
Various otological symptoms may occur in patients with SARS-CoV-2 infection. The number of typical symptoms of SARS-CoV-2 infection is positively associated with the probability of otological symptoms. However, vaccination may reduce the probability of certain otological symptoms.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染患者的耳部症状特征尚不清楚。几乎没有研究探索 2019 冠状病毒病（COVID-19）感染后耳部症状的出现。本研究旨在调查 SARS-CoV-2 感染患者中耳部症状的患病率、具体临床特征和危险因素。
我们纳入了两组患者来研究 SARS-CoV-2 感染患者中耳部症状的患病率和临床特征。第一组样本（S1）通过问卷调查从四个社区中回顾性抽取，第二组样本（S2）从门诊抽取。
S1 共纳入 189 名参与者（124 名女性[65.6%]；平均[标准差]年龄为 33.66[13.56]岁），S2 纳入 47 名参与者（25 名女性[53.2%]；平均[标准差]年龄为 45.28[14.64]岁）。S1 中最常见的耳部症状为头晕（15.9%）、耳鸣（7.9%）、耳闷（6.9%）、耳痛（5.3%）、听力损失（1.6%）和耳溢液（1.1%）。此外，对于 SARS-CoV-2 感染的每增加一个典型症状，耳部症状的风险（比值比）增加 1.33（95%置信区间：1.10-1.61，p=0.003）。未接种疫苗组的耳闷发生率高于接种两剂或三剂疫苗组（p=0.018）。
SARS-CoV-2 感染患者可能出现各种耳部症状。SARS-CoV-2 感染的典型症状数量与耳部症状的发生概率呈正相关。然而，接种疫苗可能会降低某些耳部症状的发生概率。
