Fierascu Irina, Fierascu Ioana Catalina, Brazdis Roxana Ioana, Baroi Anda Maria, Fistos Toma, Fierascu Radu Claudiu
National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM Bucharest, Emerging Nanotechnologies Group, 202 Spl. Independentei, 060021 Bucharest, Romania.
University of Medicine and Pharmacy "Carol Davila", 37 Dionisie Lupu Str., 030167 Bucharest, Romania.
Materials (Basel). 2020 Jan 25;13(3):574. doi: 10.3390/ma13030574.
Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.
植物合成纳米颗粒是一个研究不断增加的领域，每年都有大量研究发表。然而，随着该领域兴趣的不断涌现，已发表作品的质量也在不断提高，从对普通微生物菌株的常规抗氧化或抗菌研究转向对抗生素耐药菌株或抗肿瘤研究。然而，这种日益增长的兴趣在关于纳米颗粒（NPs）毒理学效应的研究中并未得到体现；这应该是最受关注的课题，因为纳米颗粒（尤其是植物合成的纳米颗粒）总体使用量的增加可能导致它们在环境（土壤、水和生物体）中的积累。本综述旨在介绍植物合成纳米颗粒作为抗菌和抗肿瘤剂应用的最新研究结果，以及它们毒理学潜力的相关结果。
