Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Department of Biomedical Engineering, Columbia University, New York City, New York, USA.
Tissue Eng Part A. 2024 Jun;30(11-12):314-321. doi: 10.1089/ten.TEA.2023.0209. Epub 2024 Feb 2.
Organoids are three-dimensional (3D) tissue models that are derived from stem cells and can closely mimic the structure and function of human organs. The ability to create organoids that recapitulate the complex cellular architecture of organs has emerged as an innovative technique in biomedical research and drug development. However, traditional methods of organoid culture are time consuming and often yield low quantities of cells, which has led to the development of 3D bioprinting of organoids from bioinks containing suspended cells and desired scaffolds. A comparison across different organoid-building techniques, focusing on 3D bioprinting and its benefits, may be helpful and was yet to be distinguished. The goal of this review is to provide an overview of the current state of 3D bioprinting of organoids and its potential applications in tissue engineering, drug screening, and regenerative medicine.
类器官是源自于干细胞的三维（3D）组织模型，可以很好地模拟人体器官的结构和功能。能够创建出能够重现器官复杂细胞结构的类器官，已经成为生物医学研究和药物开发中的一项创新技术。然而，传统的类器官培养方法耗时且往往产量低，这导致了含有悬浮细胞和所需支架的生物墨水的 3D 生物打印类器官的发展。不同类器官构建技术的比较，重点是 3D 生物打印及其优势，可能会有所帮助，而且尚未得到区分。本综述的目的是概述 3D 生物打印类器官的现状及其在组织工程、药物筛选和再生医学中的潜在应用。
