影响开角型青光眼眼角膜变形幅度的因素分析：Corvis ST 测量法。
Factors affecting corneal deformation amplitude measured by Corvis ST in eyes with open-angle glaucoma.
机构信息
Department of Glaucoma, Narayana Nethralaya, Bangalore, Karnataka, India.
Department of Glaucoma, University Eye Clinic Maastricht, University Medical Center, Maastricht, The Netherlands.
出版信息
Indian J Ophthalmol. 2024 Apr 1;72(4):533-537. doi: 10.4103/IJO.IJO_822_23. Epub 2023 Dec 15.
PURPOSE
To evaluate the factors affecting corneal deformation amplitude (DA) measured using Corvis ST in eyes with open-angle glaucoma.
METHODS
This prospective, longitudinal study included 48 eyes with open-angle glaucoma who required additional intraocular pressure (IOP)-lowering drops. All eyes underwent a complete eye examination at baseline, including a Corvis ST, which was repeated 4-8 weeks after the change in therapy. Factors affecting the corneal biomechanics, namely the DA, were determined using mixed effect models.
RESULTS
The mean age of the cohort was 65.0 ± 7.9 years. The mean IOP reduced from 23.4 ± 5.4 mmHg to 17.9 ± 5 mmHg after the change in glaucoma treatment ( P < 0.001). The DA increased from 0.89 ± 0.16 mm to 1.00 ± 0.13 mm after IOP reduction ( P < 0.001). On mixed effect model analysis, IOP (-0.02 ± 0.001, P < 0.001) and corneal pachymetry (-0.0003 ± 0.0001, P = 0.02) affected the change in the DA.
CONCLUSION
IOP and corneal pachymetry affect the DA and must be accounted for when using Corvis ST to evaluate corneal biomechanics in glaucoma.
目的
评估使用 Corvis ST 测量的开角型青光眼患者角膜变形幅度（DA）的影响因素。
方法
这是一项前瞻性、纵向研究，纳入了 48 例需要额外使用降眼压滴眼液的开角型青光眼患者。所有患者在基线时均接受了全面的眼科检查，包括 Corvis ST，在治疗方案改变后 4-8 周重复检查。使用混合效应模型确定影响角膜生物力学的因素，即 DA。
结果
队列的平均年龄为 65.0±7.9 岁。降眼压治疗后，平均眼压从 23.4±5.4mmHg 降至 17.9±5mmHg（P<0.001）。DA 从 0.89±0.16mm 增加至 1.00±0.13mm（P<0.001）。混合效应模型分析显示，眼压（-0.02±0.001，P<0.001）和角膜厚度（-0.0003±0.0001，P=0.02）影响 DA 的变化。
结论
眼压和角膜厚度会影响 DA，在使用 Corvis ST 评估青光眼患者的角膜生物力学时必须加以考虑。
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