Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, P. R. China.
School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, P. R. China.
Adv Healthc Mater. 2024 Jul;13(18):e2303532. doi: 10.1002/adhm.202303532. Epub 2024 May 25.
Repairing critical size bone defects (CSBD) is a major clinical challenge and requires effective intervention by biomaterial scaffolds. Inspired by the fact that the cartilaginous template-based endochondral ossification (ECO) process is crucial to bone healing and development, developing biomimetic biomaterials to promote ECO is recognized as a promising approach for repairing CSBD. With the unique highly hydrated 3D polymeric network, hydrogels can be designed to closely emulate the physiochemical properties of cartilage matrix to facilitate ECO. In this review, the various preparation methods of hydrogels possessing the specific physiochemical properties required for promoting ECO are introduced. The materiobiological impacts of the physicochemical properties of hydrogels, such as mechanical properties, topographical structures and chemical compositions on ECO, and the associated molecular mechanisms related to the BMP, Wnt, TGF-β, HIF-1α, FGF, and RhoA signaling pathways are further summarized. This review provides a detailed coverage on the materiobiological insights required for the design and preparation of hydrogel-based biomaterials to facilitate bone regeneration.
修复临界尺寸骨缺损（CSBD）是一项重大的临床挑战，需要生物材料支架的有效干预。受软骨模板为基础的软骨内骨化（ECO）过程对骨愈合和发育至关重要这一事实的启发，开发仿生生物材料来促进 ECO 被认为是修复 CSBD 的一种很有前途的方法。水凝胶具有独特的高水合 3D 聚合物网络，可设计为紧密模拟软骨基质的理化特性，以促进 ECO。在这篇综述中，介绍了具有促进 ECO 所需的特定理化特性的水凝胶的各种制备方法。进一步总结了水凝胶的理化特性（如机械性能、形貌结构和化学成分）对 ECO 的影响，以及与 BMP、Wnt、TGF-β、HIF-1α、FGF 和 RhoA 信号通路相关的分子机制。这篇综述详细介绍了设计和制备水凝胶基生物材料以促进骨再生所需的材料生物学见解。
