Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra, 425405, India.
Shree S K Patel College of Pharmaceutical Education and Research, Ganpat University, Mahesana, Gujarat, 384012, India.
Med Oncol. 2023 Dec 19;41(1):22. doi: 10.1007/s12032-023-02258-5.
Carcinoma is a condition that continues to pose a significant challenge, despite current medical advances. Skin carcinoma is the leading cause of cancer, and it has seen a massive increase all over the world. The challenges with current treatment are due to toxicity that leads to many more skin complications. Due to this to avoid such complications by designing diverse nanoparticles as delivery carriers, nanomedicine is employed as a hub for diagnostics and therapy. Liposomes, gold nanoparticles, transferases, nanofibers, etc., can all be used as delivery nanocarriers. These nanoparticles' structures and characteristics protect the medicine from degradation and improve its stability. Surface modifying agents and procedures are employed to functionalize nanoparticles, resulting in smart delivery systems. The application of nanotechnology-based approaches systematically increases drug delivery to target cells. Skin cancer has several challenges, including a long time to diagnose early types of cancer and a slower growth rate. This review focuses on innovative skin cancer therapy techniques, focusing on nanotechnology and the challenges associated with current treatment of skin cancer.
癌症是一种持续存在的挑战,尽管目前医学取得了进步。皮肤癌是癌症的主要原因,在全球范围内发病率大幅上升。目前治疗方法存在的挑战是由于毒性导致更多的皮肤并发症。为了避免这种并发症,通过设计各种纳米颗粒作为药物载体,纳米医学被用作诊断和治疗的中心。脂质体、金纳米颗粒、转移酶、纳米纤维等都可以作为药物递送的纳米载体。这些纳米颗粒的结构和特性可以保护药物不被降解,提高其稳定性。表面修饰剂和处理方法被用来对纳米颗粒进行功能化,从而形成智能递药系统。基于纳米技术的方法的应用系统地提高了药物向靶细胞的递送。皮肤癌面临着一些挑战,包括早期癌症的诊断时间长和生长速度较慢。本综述重点介绍了创新的皮肤癌治疗技术,重点关注了纳米技术和皮肤癌当前治疗方法所面临的挑战。