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IgM类风湿因子作为小鼠抗同种异型血清中非特异性的来源。

IgM rheumatoid factor as a source of non-specificity in murine anti-allotype sera.

作者信息

Keeler K D, Phillips J M, Dresser D W

出版信息

Immunology. 1979 May;37(1):263-71.

PMID:381175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457285/
Abstract

Anti-allotype sera have shown a breakdown of the expected specificity especially when used for the development of haemolysis of fragile target erythrocytes. IgM anti-IgG rheumatoid factor has been shown to be the source of non-specificity. Removal or destruction of IgM in an anti-allotype serum restores the expected specificity.

摘要

抗同种异型血清已显示出预期特异性的破坏，尤其是当用于诱导脆弱靶红细胞溶血时。IgM抗IgG类风湿因子已被证明是非特异性的来源。在抗同种异型血清中去除或破坏IgM可恢复预期的特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/e121d14098fd/immunology00262-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/469fb14ad577/immunology00262-0265-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/422ffbc6bd9f/immunology00262-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/41677a68d4b8/immunology00262-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/e121d14098fd/immunology00262-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/469fb14ad577/immunology00262-0265-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/422ffbc6bd9f/immunology00262-0266-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/41677a68d4b8/immunology00262-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b4/1457285/e121d14098fd/immunology00262-0268-a.jpg

相似文献

1
IgM rheumatoid factor as a source of non-specificity in murine anti-allotype sera.IgM类风湿因子作为小鼠抗同种异型血清中非特异性的来源。
Immunology. 1979 May;37(1):263-71.
2
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引用本文的文献

1
Complement activation induced by rabbit rheumatoid factor.兔类风湿因子诱导的补体激活。
Infect Immun. 1980 Jul;29(1):50-8. doi: 10.1128/iai.29.1.50-58.1980.
2
Allotype suppression of the responsiveness of adoptively transferred adult spleen cells induced by affinity prepared anti-allotype antibody.亲和制备的抗同种异型抗体诱导的过继转移成年脾细胞反应性的同种异型抑制。
Immunology. 1981 Apr;42(4):601-10.
3
Rheumatoid factors in mice: non-specific activators of heterophile rheumatoid factor production.小鼠中的类风湿因子：嗜异性类风湿因子产生的非特异性激活剂。

本文引用的文献

1
Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.通过亲和色谱法进行蛋白质纯化。琼脂糖和聚丙烯酰胺珠粒的衍生化。
J Biol Chem. 1970 Jun;245(12):3059-65.
2
Adsorbents for affinity chromatography. Use of N-hydroxysuccinimide esters of agarose.亲和层析吸附剂。琼脂糖N-羟基琥珀酰亚胺酯的应用。
Biochemistry. 1972 Jun 6;11(12):2291-9. doi: 10.1021/bi00762a013.
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Isoelectric spectra of different classes of anti-erythrocyte antibodies.不同类别抗红细胞抗体的等电谱。
Immunology. 1980 Nov;41(3):579-85.
Eur J Immunol. 1973 Aug;3(8):524-7. doi: 10.1002/eji.1830030816.
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Congenic mouse strains: the expression of a hidden immunoglobulin allotype in a congenic partner strain of BALB-c mice.同源近交系小鼠：BALB-c小鼠同源近交系伙伴中隐藏免疫球蛋白同种异型的表达。
J Exp Med. 1974 Mar 1;139(3):512-27. doi: 10.1084/jem.139.3.512.
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Antibody isoelectric spectra visualized by antigen-coated erythrocytes.通过抗原包被红细胞可视化的抗体等电谱。
Eur J Immunol. 1973 Nov;3(11):738-40. doi: 10.1002/eji.1830031116.
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Immunoglobulin allotypes of the mouse.小鼠免疫球蛋白同种异型
Biochem Soc Trans. 1976;4(1):34-8. doi: 10.1042/bst0040034.
7
Most IgM-producing cells in the mouse secrete auto-antibodies (rheumatoid factor).小鼠中大多数产生IgM的细胞会分泌自身抗体（类风湿因子）。
Nature. 1978 Aug 3;274(5670):480-3. doi: 10.1038/274480a0.
8
Induction of an IgM anti-(bovine)-IgG response in mice by bacterial lipopolysaccharide.细菌脂多糖诱导小鼠产生抗（牛）IgG IgM反应。
Nature. 1976 Dec 9;264(5586):552-4. doi: 10.1038/264552a0.