Gohji K, Sugimoto M, Ogawa T, Sugino M, Hamami G, Kamidono S, Takahashi R, Sugiyama T
Hinyokika Kiyo. 1986 Sep;32(9):1298-302.
A case of pure choriocarcinoma of the testis in a 62-year-old male is reported. The patient consulted his family physician with an enlarged but painless right scrotal containment in November, 1980. Initial diagnosis was right hydrocele testis and chronic epididymitis, and he was treated with antibiotics. However, the tumor continued to enlarge. Right high orchiectomy was performed on March, 15, 1981 under the diagnosis of suspected right testicular tumor. The resected specimen was 10 X 7 X 6 cm and elastic hard. The cut surface was dark reddish with hemorrhagic foci. Serial sections of the entire testis were made and their histopathological examinations revealed the tumor to be a classical pure choriocarcinoma of the testis. The plasma beta-HCG level was remarkably elevated, but the alpha-fetoprotein level was normal. Anticancer chemotherapy (CDDP 125 mg, MTX 20 mg, ADM 50 mg, and EDX 500 mg) was performed in eight courses after the operation. Multiple metastatic foci were present in both lungs during the treatment, and his condition gradually deteriorated. Therefore, he was transferred to our hospital. Aggressive anticancer treatment could not be given because of his poor general condition, and he died on May, 16, 1982 of carcinomatosis. The autopsy revealed multiple nodular metastasis of the tumor to bilateral lungs, bilateral adrenal glands and right kidney. There was no metastasis to the lymph nodes. The metastatic lesions, macrospically dark reddish with hemorrhagic foci, were histopathologically pure choriocarcinoma.
报告了一例62岁男性睾丸纯绒毛膜癌病例。1980年11月,患者因右侧阴囊无痛性肿大就诊于家庭医生。初步诊断为右侧睾丸鞘膜积液和慢性附睾炎,给予抗生素治疗。然而,肿瘤持续增大。1981年3月15日,在怀疑右侧睾丸肿瘤的诊断下进行了右侧高位睾丸切除术。切除标本大小为10×7×6cm,质地硬且有弹性。切面呈暗红色,有出血灶。对整个睾丸制作了连续切片,组织病理学检查显示肿瘤为典型的睾丸纯绒毛膜癌。血浆β-HCG水平显著升高,但甲胎蛋白水平正常。术后进行了8个疗程的抗癌化疗(顺铂125mg、甲氨蝶呤20mg、阿霉素50mg和依托泊苷500mg)。治疗期间双肺出现多个转移灶,病情逐渐恶化。因此,他被转至我院。由于全身状况较差,无法进行积极的抗癌治疗,患者于1982年5月16日死于癌病。尸检显示肿瘤转移至双侧肺、双侧肾上腺和右肾,呈多个结节状,无淋巴结转移。转移灶肉眼观呈暗红色,有出血灶,组织病理学检查为纯绒毛膜癌。