Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
School of Pharmacy, Shanxi Medical University, Taiyuan, 030600, China.
Stem Cell Res Ther. 2023 Dec 20;14(1):381. doi: 10.1186/s13287-023-03587-y.
With the continuous improvement of human technology, the medical field has gradually moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool, cell therapy has successfully created a research boom in the modern medical field. Mesenchymal stem cells (MSCs) are derived from early mesoderm and have high self-renewal and multidirectional differentiation ability, and have become one of the important cores of cell therapy research by virtue of their immunomodulatory and tissue repair capabilities. In recent years, the application of MSCs in various diseases has received widespread attention, but there are still various problems in the treatment of MSCs, among which the heterogeneity of MSCs may be one of the causes of the problem. In this paper, we review the correlation of MSCs heterogeneity to provide a basis for further reduction of MSCs heterogeneity and standardization of MSCs and hope to provide a reference for cell therapy.
随着人类技术的不断提高，医学领域逐渐从分子治疗转向细胞治疗。细胞治疗作为一种安全有效的治疗工具，在现代医学领域成功掀起了研究热潮。间充质干细胞（MSCs）来源于早期中胚层，具有高自我更新和多向分化能力，凭借其免疫调节和组织修复能力，已成为细胞治疗研究的重要核心之一。近年来，MSCs 在各种疾病中的应用受到广泛关注，但在 MSCs 的治疗中仍存在各种问题，其中 MSCs 的异质性可能是问题之一。本文综述了 MSCs 异质性的相关性，为进一步降低 MSCs 异质性和规范 MSCs 提供依据，希望为细胞治疗提供参考。
