Reichley K B, Mueller W H, Hanis C L, Joos S K, Tulloch B R, Barton S, Schull W J
Am J Epidemiol. 1987 Mar;125(3):373-86. doi: 10.1093/oxfordjournals.aje.a114544.
The association between body fat distribution patterns and cardiovascular disease risk variables (high density lipoprotein (HDL) cholesterol, total cholesterol, diastolic and systolic blood pressures, and fasting blood glucose levels) was sought in a sample of Mexican American adults who were studied during 1981-1983 in Starr County, Texas. In the sample, all diabetics were excluded to see whether centralized obesity carried any risk for cardiovascular disease independent of diabetes. A component of centralized body fat distribution was identified through the use of principal components analysis of five skinfold measurements, which included the upper and lower extremities and trunk areas. The centralized obese were compared with generalized (peripheral) obese and nonobese controls in four subgroups of the population: younger and older adult males and females. The means of all cardiovascular risk variables were in a direction indicating that the centralized obese were significantly at greater risk than nonobese controls (in particular, HDL cholesterol, total cholesterol, and blood glucose levels). The generalized obese differed from the centralized obese in having significantly lower blood glucose levels, and tended to be intermediate between centralized obese and nonobese controls in the other variables. The data confirm that centralized obesity as defined by a linear combination of skinfold measures works in the same way as the waist-to-hip circumference ratio in describing a body build factor which heightens the risk of cardiovascular disease in the obese independent of the clinical diabetic state.
1981年至1983年期间，在得克萨斯州斯塔尔县对墨西哥裔美国成年人样本进行了研究，以探寻身体脂肪分布模式与心血管疾病风险变量（高密度脂蛋白（HDL）胆固醇、总胆固醇、舒张压和收缩压以及空腹血糖水平）之间的关联。在该样本中，所有糖尿病患者均被排除在外，以观察中心性肥胖是否独立于糖尿病而对心血管疾病构成任何风险。通过对包括上肢、下肢和躯干区域在内的五项皮褶测量值进行主成分分析，确定了中心性身体脂肪分布的一个组成部分。在该人群的四个亚组中，即年轻和年长的成年男性及女性，对中心性肥胖者与全身性（外周性）肥胖者及非肥胖对照组进行了比较。所有心血管疾病风险变量的均值都表明，中心性肥胖者比非肥胖对照组的风险显著更高（尤其是HDL胆固醇、总胆固醇和血糖水平）。全身性肥胖者与中心性肥胖者的不同之处在于血糖水平显著较低，在其他变量方面则倾向于介于中心性肥胖者和非肥胖对照组之间。数据证实，由皮褶测量值的线性组合定义的中心性肥胖与腰臀围比在描述一种体型因素时的作用方式相同，这种体型因素会增加肥胖者独立于临床糖尿病状态之外的心血管疾病风险。
