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乳香精油及其负载固体脂质纳米粒通过 MAPK 和 PI3K/AKT 信号通路对 UVB 诱导的大鼠光损伤的保护作用；一种有前途的抗衰老疗法。

Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

出版信息

PLoS One. 2023 Dec 21;18(12):e0294067. doi: 10.1371/journal.pone.0294067. eCollection 2023.

DOI:10.1371/journal.pone.0294067
PMID:38127865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10735031/
Abstract

Frankincense oil has gained increased popularity in skin care, yet its anti-aging effect remains unclear. The current study aimed to investigate the anti-photoaging effect of frankincense (Boswellia papyrifera (Del.) Hochst., Family Burseraceae) essential oil in an in vivo model. The oil was initially extracted by two methods: hydro-distillation (HD) and microwave-assisted hydro-distillation (MAHD). GC/MS analysis revealed the dominance of n-octyl acetate, along with other marker compounds of B. papyrifera including octanol and diterpene components (verticilla 4(20) 7, 11-triene and incensole acetate). Thereafter, preliminary investigation of the anti-collagenase and anti-elastase activities of the extracted oils revealed the superior anti-aging effect of HD-extracted oil (FO), comparable to epigallocatechin gallate. FO was subsequently formulated into solid lipid nanoparticles (FO-SLNs) via high shear homogenization to improve its solubility and skin penetration characteristics prior to in vivo testing. The optimimal formulation prepared with 0.5% FO, and 4% Tween® 80, demonstrated nanosized spherical particles with high entrapment efficiency percentage and sustained release for 8 hours. The anti-photoaging effect of FO and FO-SLNs was then evaluated in UVB-irradiated hairless rats, compared to Vitamin A palmitate as a positive standard. FO and FO-SLNs restored the antioxidant capacity (SOD and CAT) and prohibited inflammatory markers (IL6, NFκB p65) in UVB-irradiated rats via downregulation of MAPK (pERK, pJNK, and pp38) and PI3K/AKT signaling pathways, alongside upregulating TGF-β expression. Subsequently, our treatments induced Procollagen I synthesis and downregulation of MMPs (MMP1, MMP9), where FO-SLNs exhibited superior anti-photoaging effect, compared to FO and Vitamin A, highlighting the use of SLNs as a promising nanocarrier for FO. In particular, FO-SLNs revealed normal epidermal and dermal histological structures, protected against UVβ-induced epidermal thickness and dermal collagen degradation. Our results indicated the potential use of FO-SLNs as a promising topical anti-aging therapy.

摘要

乳香精油在皮肤护理中的应用日益普及，但它的抗衰老作用尚不清楚。本研究旨在体内模型中研究乳香（Boswellia papyrifera（Del.）Hochst.，Burseraceae 科）精油的抗光老化作用。该油最初通过两种方法提取：水蒸馏（HD）和微波辅助水蒸馏（MAHD）。GC/MS 分析表明，乙酸正辛酯占主导地位，同时还有 B. papyrifera 的其他标记化合物，包括辛醇和二萜成分（verticilla 4(20)7,11-三烯和 incensole 乙酸酯）。此后，对提取油的抗胶原酶和抗弹性蛋白酶活性的初步研究表明，HD 提取油（FO）具有优越的抗衰老作用，可与表没食子儿茶素没食子酸酯相媲美。随后，FO 通过高剪切匀化制成固体脂质纳米粒（FO-SLNs），以提高其在体内试验前的溶解度和皮肤穿透特性。用 0.5%FO 和 4%吐温®80 制备的最佳配方显示出纳米级球形颗粒，具有高包封效率百分比和 8 小时的持续释放。然后，将 FO 和 FO-SLNs 的抗光老化作用与维生素 A 棕榈酸酯作为阳性标准在 UVB 照射的无毛大鼠中进行了评估。FO 和 FO-SLNs 通过下调 MAPK（pERK、pJNK 和 pp38）和 PI3K/AKT 信号通路，同时上调 TGF-β表达，恢复了抗氧化能力（SOD 和 CAT）并抑制了 UVB 照射大鼠中的炎症标志物（IL6、NFκB p65）。随后，我们的治疗诱导了原胶原蛋白 I 的合成和 MMPs（MMP1、MMP9）的下调，其中 FO-SLNs 表现出比 FO 和维生素 A 更好的抗光老化作用，突出了 SLNs 作为 FO 的有前途的纳米载体的使用。特别是，FO-SLNs 显示出正常的表皮和真皮组织学结构，可防止 UVβ 诱导的表皮厚度和真皮胶原降解。我们的结果表明，FO-SLNs 作为一种有前途的局部抗衰老治疗方法具有潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/0e9bed6f3739/pone.0294067.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/fc012b9f55bc/pone.0294067.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/43d8d4b8176e/pone.0294067.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/081286d34ff0/pone.0294067.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/47bd5cdb3ec9/pone.0294067.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/bb0641cad3c7/pone.0294067.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/1795e28aae8b/pone.0294067.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/0e9bed6f3739/pone.0294067.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/fc012b9f55bc/pone.0294067.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/43d8d4b8176e/pone.0294067.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/081286d34ff0/pone.0294067.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/47bd5cdb3ec9/pone.0294067.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/bb0641cad3c7/pone.0294067.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/1795e28aae8b/pone.0294067.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9315/10735031/0e9bed6f3739/pone.0294067.g007.jpg

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Front Pharmacol. 2025-5-6

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Front Pharmacol. 2025-4-17

[3]
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Front Med (Lausanne). 2025-1-13

[5]
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3 Biotech. 2025-1

[6]
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[1]
Standardization and quantitative analysis of Araucaria Heterophylla extract via an UPLC-MS/MS method and its formulation as an antibacterial phytonanoemulsion gel.

Sci Rep. 2022-7-22

[2]
A Cosmeceutical Topical Water-in-Oil Nanoemulsion of Natural Bioactives: Design of Experiment, in vitro Characterization, and in vivo Skin Performance Against UVB Irradiation-Induced Skin Damages.

Int J Nanomedicine. 2022

[3]
Nuclear factor-kappa B and effector molecules in photoaging.

Cutan Ocul Toxicol. 2022-6

[4]
Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway.

Sci Rep. 2022-4-21

[5]
Tacrolimus-Loaded Solid Lipid Nanoparticle Gel: Formulation Development and In Vitro Assessment for Topical Applications.

Gels. 2022-2-18

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Int J Pharm. 2021-11-20

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Topical Delivery of Geranium/Calendula Essential Oil-Entrapped Ethanolic Lipid Vesicular Cream to Combat Skin Aging.

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[9]
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[10]
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