Hao Yiwen, Lin Xia, Liu Wenwen, Jiang Tinghongyang, Zhang Xing, Yang Shasha, Huang You, Lai Wenjing, Fu Chaomei, Zhang Zhen
School of Pharmacy, School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu, China.
Sci Rep. 2025 Jan 2;15(1):402. doi: 10.1038/s41598-024-84571-1.
Plant extracts, especially herbal extracts, are in line with the cosmetics development trend of natural and safe in today's world. Dried ginger essential oil (DGEO) is a fragrant oily liquid extracted from the dried roots of Zingiber officinale Rosc. This research investigated DGEO could effectively inhibit Staphylococcus aureus and Propionibacterium acnes. And delay skin aging in mice by down-regulating the expression of TNF-α and the production of MMP-1. These indicates that DGEO has antibacterial and anti-aging effects, and has the potential in beauty and skin care. However, DGEO is easy to volatilize, so it is lack of stability, and the application of DGEO is greatly limited. Therefore, we aim to improve the stability of DGEO and expand its application in facial mask. To achieve this, DGEO was firstly complexed with the β-cyclodextrin (β-CD) to prepare DGEO-β-CD-IC. Then, electrospinning was used to make DGEO-βCD-IC into a nanofiber facial mask. In this process, we found that the thermal stability of DGEO-βCD-IC was significantly improved, and the degradation process was slower than that of physical mixture. During the preparation of the nanofiber mask, DGEO did not undergo a chemical reaction. And the fibers of facial mask were evenly distributed, with smooth surfaces and tight structures. Its diameter was between 90 and 110 nm. And the facial mask had good hydrophilic performance and moisturizing efficacy. It could increase the skin water content by 47.82% on average. What's more, the safety tests showed that the facial mask was mild and safe. These results show that we improve the stability of DGEO and successfully develop a promising application prospects nanofiber mask. This work may enrich the use of herbal extracts in skincare products.
植物提取物，尤其是草药提取物，符合当今世界天然、安全的化妆品发展趋势。干姜精油（DGEO）是从姜科植物姜的干燥根茎中提取的一种芳香油状液体。本研究考察了DGEO能有效抑制金黄色葡萄球菌和痤疮丙酸杆菌，并通过下调肿瘤坏死因子-α的表达和基质金属蛋白酶-1的产生来延缓小鼠皮肤衰老。这些表明DGEO具有抗菌和抗老化作用，在美容护肤方面具有潜力。然而，DGEO易挥发，稳定性差，其应用受到很大限制。因此，我们旨在提高DGEO的稳定性并扩大其在面膜中的应用。为此，首先将DGEO与β-环糊精（β-CD）络合制备DGEO-β-CD-IC。然后，采用静电纺丝法将DGEO-βCD-IC制成纳米纤维面膜。在此过程中，我们发现DGEO-βCD-IC的热稳定性显著提高，降解过程比物理混合物慢。在纳米纤维面膜的制备过程中，DGEO未发生化学反应。面膜纤维分布均匀，表面光滑，结构紧密。其直径在90至110纳米之间。面膜具有良好的亲水性和保湿功效，平均可使皮肤含水量增加47.82%。此外，安全性测试表明该面膜温和安全。这些结果表明，我们提高了DGEO的稳定性，并成功开发出一种具有广阔应用前景的纳米纤维面膜。这项工作可能会丰富草药提取物在护肤品中的应用。
