Hu Yibao, He Bisha, Cao Qian, Li Yue, Tang Yun, Cao Ting, Peng Binfeng, Zhou Xiangping, Liu Shuangquan
Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Front Mol Biosci. 2023 Dec 7;10:1315935. doi: 10.3389/fmolb.2023.1315935. eCollection 2023.
Ferroptosis is a type of programmed cell death that pathogens can leverage to enhance their replication, transmission, and pathogenicity. Hosts typically combat pathogenic infections by utilizing oxidative stress as a defense mechanism. Nonetheless, some pathogens can trigger considerable oxidative stress while infecting, inducing an intense inflammatory response in the host's immune system and activating cell death. The process of ferroptosis is closely linked to oxidative stress, with their interaction exerting a substantial impact on the outcome of infectious diseases. This article presents an overview of the interrelated mechanisms of both Ferroptosis and oxidative stress in infectious diseases, identifying potential targets for treating such diseases in the context of their interaction.
铁死亡是一种程序性细胞死亡,病原体可利用它来增强自身的复制、传播和致病性。宿主通常通过利用氧化应激作为防御机制来对抗病原体感染。尽管如此,一些病原体在感染时会引发相当程度的氧化应激,在宿主免疫系统中诱导强烈的炎症反应并激活细胞死亡。铁死亡过程与氧化应激密切相关,它们之间的相互作用对传染病的结局有重大影响。本文概述了传染病中铁死亡和氧化应激的相关机制,在它们的相互作用背景下确定了治疗此类疾病的潜在靶点。