Ducoloné A, Vandevenne A, Jouin H, Grob J C, Coumaros D, Meyer C, Burghard G, Methlin G, Hollender L
Am Rev Respir Dis. 1987 Feb;135(2):327-32. doi: 10.1164/arrd.1987.135.2.327.
To determine the relationship between gastroesophageal (GE) reflux and pulmonary disease, we studied 21 asthmatics, 30 chronic bronchitics, 6 patients with GE reflux and no pulmonary symptoms, and 10 control subjects; GE reflux was diagnosed by pH monitoring and GE scintiscanning. Frequency of GE reflux in the asthmatics was 57%; in the chronic bronchitics it was 56%. Pulmonary function tests did not show any differences between patients with or without reflux. The GE reflux episodes were more numerous but shorter in asthmatics than in chronic bronchitics. Patients with digestive symptoms alone were no different from chronic bronchitics with respect to reflux. The mechanism whereby reflux triggers pulmonary problems was investigated using the following 2 tests: scintiscan for pulmonary aspiration, and esophageal acid infusion (0.1N HCl). Six pulmonary aspirations were detected. Only asthmatics, with or without reflux, showed any significant variations in maximal expiratory flow at 50% and 25% of VC after HCl infusion. Thus, our results show that asthmatics differ from chronic bronchitics by the characteristics of their reflux.
为了确定胃食管反流（GE）与肺部疾病之间的关系，我们研究了21名哮喘患者、30名慢性支气管炎患者、6名有GE反流但无肺部症状的患者以及10名对照受试者；通过pH监测和GE闪烁扫描诊断GE反流。哮喘患者中GE反流的发生率为57%；慢性支气管炎患者中为56%。肺功能测试显示有反流和无反流的患者之间没有任何差异。哮喘患者的GE反流发作次数更多，但比慢性支气管炎患者的发作时间更短。仅患有消化症状的患者在反流方面与慢性支气管炎患者没有差异。使用以下两项测试研究了反流引发肺部问题的机制：肺部吸入闪烁扫描和食管酸灌注（0.1N HCl）。检测到6次肺部吸入。仅哮喘患者，无论有无反流，在注入HCl后，其肺活量（VC）的50%和25%时的最大呼气流量均出现了显著变化。因此，我们的结果表明，哮喘患者的反流特征与慢性支气管炎患者不同。
