Hampl H, Paeprer H, Unger V, Kessel M W
J Dial. 1979;3(1):51-71. doi: 10.3109/08860227909064912.
Circulatory parameters were determined by cardiac catheterization in patients on maintenance hemodialysis. They were studied in three groups during conventional hemodialysis, sequential ultrafiltration and hemofiltration. All three groups revealed significant reduction of cardiac output, stroke volume, pulmonary artery pressure and plasma volume. In the hemodialysis group hemodynamic parameters were unstable; specifically, hypotension, increased heart rate, and only minimal increase of peripheral resistance were observed. The other two groups showed only minor changes in circulatory parameters despite high ultrafiltration rates. Blood pressure and heart rate remained stable. On the other hand, peripheral vascular resistance increased remarkably. There is compelling evidence that during hemofiltration and sequential ultrafiltration, the patient's ability for vasoconstrictive counterregulation is better maintained than during conventional hemodialysis.
通过心脏导管插入术测定维持性血液透析患者的循环参数。在常规血液透析、序贯超滤和血液滤过过程中对三组患者进行了研究。所有三组均显示心输出量、每搏输出量、肺动脉压和血浆容量显著降低。血液透析组的血流动力学参数不稳定；具体而言，观察到低血压、心率增加，而外周阻力仅略有增加。尽管超滤率很高，但其他两组的循环参数仅发生了轻微变化。血压和心率保持稳定。另一方面，外周血管阻力显著增加。有确凿证据表明，与常规血液透析相比，血液滤过和序贯超滤过程中患者的血管收缩性反调节能力得到了更好的维持。
