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Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.药物引起的类风湿关节炎中多形核细胞杀菌能力受损。
Ann Rheum Dis. 1987 Jan;46(1):46-50. doi: 10.1136/ard.46.1.46.
2
Ketoprofen-induced reduction of polymorphonuclear cell activation in rheumatoid arthritis.酮洛芬诱导类风湿关节炎中多形核细胞活化的降低。
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Bactericidal defect of neutrophils in a guinea pig model of thermal injury is related to elevation of intracellular cyclic-3',5'-adenosine monophosphate.热损伤豚鼠模型中中性粒细胞的杀菌缺陷与细胞内3',5'-环磷酸腺苷升高有关。
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In vitro effect of different non-steroidal anti-inflammatory drugs on human polymorphonuclear leukocyte activity measured by luminol-dependent chemiluminescence of the whole blood.通过全血鲁米诺依赖性化学发光法测定不同非甾体抗炎药对人多形核白细胞活性的体外作用。
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本文引用的文献

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FOLIC-ACID DEFICIENCY IN RHEUMATOID ARTHRITIS.类风湿关节炎中的叶酸缺乏
Br Med J. 1964 Jan 25;1(5377):212-7. doi: 10.1136/bmj.1.5377.212.
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1958 Revision of diagnostic criteria for rheumatoid arthritis.1958年类风湿关节炎诊断标准修订版。
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3
Polymorphonuclear cell function in rheumatoid arthritis and in Felty's syndrome.类风湿关节炎和费尔蒂综合征中的多形核细胞功能
Ann Rheum Dis. 1981 Aug;40(4):370-5. doi: 10.1136/ard.40.4.370.
4
Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid factor, immune complexes and C-reactive protein with each other and with clinical features of disease activity.类风湿关节炎中血浆C3d浓度、血清类风湿因子、免疫复合物及C反应蛋白之间的相关性以及与疾病活动临床特征的相关性。
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5
Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid.类风湿血清和滑液对中性粒细胞化学发光的直接激活作用。
Ann Rheum Dis. 1983 Apr;42(2):158-62. doi: 10.1136/ard.42.2.158.
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Folic acid deficiency and neutrophil dysfunction.叶酸缺乏与中性粒细胞功能障碍。
Am J Med. 1982 Nov;73(5):652-7. doi: 10.1016/0002-9343(82)90406-5.
7
The use of C3d as a means of monitoring clinical activity in systemic lupus erythematosus and rheumatoid arthritis.将C3d用作监测系统性红斑狼疮和类风湿性关节炎临床活动的一种手段。
Ann Rheum Dis. 1983 Dec;42(6):668-71. doi: 10.1136/ard.42.6.668.
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The role of granulocytes in inflammation.粒细胞在炎症中的作用。
Scand J Rheumatol. 1984;13(2):163-72. doi: 10.3109/03009748409100381.
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Leukocyte oxidase: defective activity in chronic granulomatous disease.白细胞氧化酶：慢性肉芽肿病中的活性缺陷
Science. 1967 Feb 17;155(3764):835-6. doi: 10.1126/science.155.3764.835.
10
Effect of phenylbutazone on phagocytosis and intracellular killing by guinea pig polymorphonuclear leukocytes.保泰松对豚鼠多形核白细胞吞噬作用及细胞内杀伤的影响。
J Bacteriol. 1968 Dec;96(6):1982-90. doi: 10.1128/jb.96.6.1982-1990.1968.

药物引起的类风湿关节炎中多形核细胞杀菌能力受损。

Drug induced impairment of polymorphonuclear cell bactericidal ability in rheumatoid arthritis.

作者信息

Youinou P, Le Goff P

出版信息

Ann Rheum Dis. 1987 Jan;46(1):46-50. doi: 10.1136/ard.46.1.46.

DOI:10.1136/ard.46.1.46
PMID:3813675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1002057/
Abstract

Thirty three patients with rheumatoid arthritis (RA) treated only with non-steroidal anti-inflammatory drugs were divided into two groups according to the drug received (group A: diclofenac, group B: indomethacin or ketoprofen), and their polymorphonuclear (PMN) cell functions were investigated. We found that bactericidal ability was the only function significantly impaired in group A as compared with group B patients and normal controls. This modification correlated well with the reduction of control PMN bactericidal ability when this test was carried out in patient plasma. These differences between drug effects might explain some of the discrepancies between reports of PMN cell functions in RA.

摘要

33例仅接受非甾体抗炎药治疗的类风湿关节炎（RA）患者，根据所接受的药物分为两组（A组：双氯芬酸，B组：吲哚美辛或酮洛芬），并对其多形核（PMN）细胞功能进行了研究。我们发现，与B组患者和正常对照组相比，A组中唯一显著受损的功能是杀菌能力。当在患者血浆中进行该试验时，这种改变与对照PMN杀菌能力的降低密切相关。药物作用之间的这些差异可能解释了RA中PMN细胞功能报告之间的一些差异。