将C3d用作监测系统性红斑狼疮和类风湿性关节炎临床活动的一种手段。
The use of C3d as a means of monitoring clinical activity in systemic lupus erythematosus and rheumatoid arthritis.
作者信息
Morrow W J, Williams D J, Ferec C, Casburn-Budd R, Isenberg D A, Paice E, Snaith M L, Youinou P, Le Goff P
出版信息
Ann Rheum Dis. 1983 Dec;42(6):668-71. doi: 10.1136/ard.42.6.668.
Abstract
Plasma samples from 44 patients with systemic lupus erythematosus (SLE) and 43 with rheumatoid arthritis (RA) were assayed for C3d, a breakdown product of the third component of complement (C3), which was also measured in parallel. Levels of C3d varied in direct proportion with disease activity in RA, whereas C3 showed little change. Although C3d values also increased with worsening clinical condition in SLE, this trend was not considered to be sufficiently clear to be useful and did not provide any advantage over the routinely performed C3 assay.
摘要
对44例系统性红斑狼疮（SLE）患者和43例类风湿关节炎（RA）患者的血浆样本进行了C3d检测，C3d是补体第三成分（C3）的降解产物，同时也对C3进行了平行检测。在RA中，C3d水平与疾病活动度成正比，而C3变化不大。虽然在SLE中C3d值也随着临床病情恶化而升高，但这种趋势被认为不够明显，没有实用价值，并且与常规进行的C3检测相比没有任何优势。
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