Zolnikova Oxana, Dzhakhaya Natiya, Bueverova Elena, Sedova Alla, Kurbatova Anastasia, Kryuchkova Kira, Butkova Tatyana, Izotov Alexander, Kulikova Ludmila, Yurku Kseniya, Chekulaev Pavel, Zaborova Victoria
Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Institute of Public Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Microorganisms. 2023 Nov 23;11(12):2848. doi: 10.3390/microorganisms11122848.
The development of many human disorders, including celiac disease (CD), is thought to be influenced by the microbiota of the gastrointestinal tract and its metabolites, according to current research. This study's goal was to provide a concise summary of the information on the contribution of the intestinal microbiota to the CD pathogenesis, which was actively addressed while examining the reported pathogenesis of celiac disease (CD). We assumed that a change in gluten tolerance is formed under the influence of a number of different factors, including genetic predisposition and environmental factors. In related investigations, researchers have paid increasing attention to the study of disturbances in the composition of the intestinal microbiota and its functional activity in CD. A key finding of our review is that the intestinal microbiota has gluten-degrading properties, which, in turn, may have a protective effect on the development of CD. The intestinal microbiota contributes to maintaining the integrity of the intestinal barrier, preventing the formation of a "leaky" intestine. On the contrary, a change in the composition of the microbiota can act as a significant link in the pathogenesis of gluten intolerance and exacerbate the course of the disease. The possibility of modulating the composition of the microbiota by prescribing probiotic preparations is being considered. The effectiveness of the use of probiotics containing and bacteria in experimental and clinical studies as a preventive and therapeutic agent has been documented.
根据目前的研究，包括乳糜泻（CD）在内的许多人类疾病的发展被认为受到胃肠道微生物群及其代谢产物的影响。本研究的目的是简要总结关于肠道微生物群对CD发病机制贡献的信息，这在研究乳糜泻（CD）报道的发病机制时得到了积极探讨。我们假设麸质耐受性的改变是在包括遗传易感性和环境因素在内的多种不同因素影响下形成的。在相关研究中，研究人员越来越关注CD中肠道微生物群组成紊乱及其功能活性的研究。我们综述的一个关键发现是肠道微生物群具有降解麸质的特性，这反过来可能对CD的发展具有保护作用。肠道微生物群有助于维持肠道屏障的完整性，防止形成“渗漏性”肠道。相反，微生物群组成的变化可能是麸质不耐受发病机制中的一个重要环节，并加剧疾病进程。正在考虑通过开益生菌制剂来调节微生物群组成的可能性。含有 和 细菌的益生菌在实验和临床研究中作为预防和治疗剂使用的有效性已得到证实。
