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采用 UPLC-QTOF-MS 比较不同物种的代谢组学。

Comparison of the Metabolomics of Different Species by UPLC-QTOF-MS.

机构信息

Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Hunan Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, Changsha 410208, China.

出版信息

Int J Mol Sci. 2023 Dec 5;24(24):17148. doi: 10.3390/ijms242417148.

DOI:10.3390/ijms242417148
PMID:38138977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10742841/
Abstract

Sw. (family Orchidaceae) is a renowned edible and medicinal plant in China. Although widely cultivated and used, less research has been conducted on differential species. In this study, stems from seven distinct species were subjected to UPLC-QTOF-MS/MS analysis. A total of 242 metabolites were annotated, and multivariate statistical analysis was employed to explore the variance in the extracted metabolites across the various groups. The analysis demonstrated that displays conspicuous differences from other species of . Specifically, stands out from the remaining six taxa of based on 170 distinct metabolites, mainly terpene and flavonoid components, associated with cysteine and methionine metabolism, flavonoid biosynthesis, and galactose metabolism. It is believed that the variations between and other species are mainly attributed to three metabolite synthesis pathways. By comparing the chemical composition of seven species of , this study identified the qualitative components of each species. was found to differ significantly from other species, with higher levels of terpenoids, flavonoids, and other compounds that are for the cardiovascular field. By comparing the chemical composition of seven species of , these qualitative components have relevance for establishing quality standards for .

摘要

铁皮石斛（家族 Orchidaceae）是中国著名的食用和药用植物。尽管广泛种植和使用，但对不同物种的研究较少。在这项研究中，来自七个不同物种的茎进行了 UPLC-QTOF-MS/MS 分析。共注释了 242 种代谢物，并采用多元统计分析方法来探讨不同组之间提取代谢物的差异。分析表明，与其他铁皮石斛物种相比，铁皮石斛表现出明显的差异。具体而言，铁皮石斛与其余六种铁皮石斛属的种基于 170 种独特的代谢物表现出明显差异，主要为萜类化合物和类黄酮成分，与半胱氨酸和蛋氨酸代谢、类黄酮生物合成和半乳糖代谢有关。据信，铁皮石斛和其他铁皮石斛属物种之间的差异主要归因于三种代谢物合成途径。通过比较七种铁皮石斛属物种的化学成分，本研究确定了每个物种的定性成分。与其他物种相比，铁皮石斛表现出显著差异，具有更高水平的萜类化合物、类黄酮和其他化合物，这些化合物在心血管领域具有重要作用。通过比较七种铁皮石斛属物种的化学成分，这些定性成分对于建立铁皮石斛的质量标准具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/fb0fd3ed05c4/ijms-24-17148-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/084691206819/ijms-24-17148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/0389de735b3d/ijms-24-17148-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/c239a491c553/ijms-24-17148-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/6389c3c9ba54/ijms-24-17148-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/612dcef08355/ijms-24-17148-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/fb0fd3ed05c4/ijms-24-17148-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/084691206819/ijms-24-17148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/0389de735b3d/ijms-24-17148-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/c239a491c553/ijms-24-17148-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/6389c3c9ba54/ijms-24-17148-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3946/10742841/fb0fd3ed05c4/ijms-24-17148-g006.jpg

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