Department of Ophthalmology, University of Bonn, Germany.
Retina. 2024 May 1;44(5):844-851. doi: 10.1097/IAE.0000000000004029.
BACKGROUND/PURPOSE: Central serous chorioretinopathy (CSC) is associated with pachychoroid and dysfunctional retinal pigment epithelium. Autofluorescence (AF) is typically altered. The authors performed this study to quantify these alterations using quantitative AF (qAF) in patients with CSC and in their fellow eye in comparison with a healthy control group.
Patients with CSC and healthy controls were recruited prospectively. All patients received a full clinical examination including best-corrected visual acuity, enhanced depth imaging-optical coherence tomography, and qAF. Quantitative autofluorescence images were taken with a confocal scanning laser ophthalmoscope (Heidelberg Engineering). Quantitative autofluorescence values were assessed in specified regions of the inner eight and the middle ring of the Delori grid.
In total, 141 eyes of 77 patients with CSC were included. Ninety eyes had a manifest CSC (group 1) while 51 fellow eyes (group 2) did not show signs of CSC. There were no significant differences of qAF values between these two groups: mean qAF values were 241.3 (inner eight) and 212.8 (middle ring) in group 1 and 235.9 (inner eight) and 210.0 (middle ring) in group 2 ( P = 1.0 and 1.0). We compared these eyes with healthy controls comprising 39 eyes. Quantitative autofluorescence signals (inner eight: 164.7; middle ring: 148.9) differed significantly compared with both CSC manifest ( P < 0.001) and fellow eyes ( P < 0.001).
Our results show that patients with CSC have increased qAF values in both eyes with manifest CSC and asymptomatic, clinically unremarkable fellow eyes in comparison with healthy controls. This finding suggests that qAF alterations are present even before clinical signs can be observed.
背景/目的：中心性浆液性脉络膜视网膜病变（CSC）与厚脉络膜和功能障碍的视网膜色素上皮有关。自发荧光（AF）通常会发生改变。作者进行了这项研究，旨在通过 CSC 患者及其对侧眼的定量 AF（qAF）来定量这些改变，并与健康对照组进行比较。
前瞻性招募 CSC 患者和健康对照者。所有患者均接受全面的临床检查，包括最佳矫正视力、增强深度成像光学相干断层扫描和 qAF。使用共焦扫描激光检眼镜（海德堡工程公司）拍摄定量自发荧光图像。在 Delori 网格的内八环和中环指定区域评估定量自发荧光值。
共纳入 77 例 CSC 患者的 141 只眼。90 只眼有明显 CSC（组 1），51 只对侧眼（组 2）未出现 CSC 迹象。两组 qAF 值无显著差异：组 1 的平均 qAF 值分别为内八环 241.3（212.8）和中环 212.8（210.0），组 2 分别为 235.9（210.0）和 210.0（210.0）（P=1.0 和 1.0）。我们将这些眼与包括 39 只眼的健康对照组进行比较。与 CSC 显性（P<0.001）和对侧眼（P<0.001）相比，定量自发荧光信号（内八环：164.7；中环：148.9）差异显著。
我们的结果表明，与健康对照组相比，CSC 显性和无症状、临床无明显异常的对侧眼中，CSC 患者的 qAF 值均增加。这一发现表明，即使在临床体征出现之前，qAF 改变就已经存在。
