Celikkin Nehar, Presutti Dario, Maiullari Fabio, Fornetti Ersilia, Agarwal Tarun, Paradiso Alessia, Volpi Marina, Święszkowski Wojciech, Bearzi Claudia, Barbetta Andrea, Zhang Yu Shrike, Gargioli Cesare, Rizzi Roberto, Costantini Marco
Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.
Istituto Nazionale Genetica Molecolare INGM "Romeo Ed Enrica Invernizzi", Milan, Italy.
Front Bioeng Biotechnol. 2021 Sep 16;9:732130. doi: 10.3389/fbioe.2021.732130. eCollection 2021.
In the last decades, biomedical research has significantly boomed in the academia and industrial sectors, and it is expected to continue to grow at a rapid pace in the future. An in-depth analysis of such growth is not trivial, given the intrinsic multidisciplinary nature of biomedical research. Nevertheless, technological advances are among the main factors which have enabled such progress. In this review, we discuss the contribution of two state-of-the-art technologies-namely biofabrication and organ-on-a-chip-in a selection of biomedical research areas. We start by providing an overview of these technologies and their capacities in fabricating advanced tissue/organ models. We then analyze their impact on addressing a range of current biomedical challenges. Ultimately, we speculate about their future developments by integrating these technologies with other cutting-edge research fields such as artificial intelligence and big data analysis.
在过去几十年中，生物医学研究在学术界和工业领域都取得了显著的蓬勃发展，预计未来还将继续快速增长。鉴于生物医学研究固有的多学科性质，对这种增长进行深入分析并非易事。然而，技术进步是推动这一进展的主要因素之一。在本综述中，我们将讨论两种前沿技术——生物制造和芯片器官——在一系列生物医学研究领域中的贡献。我们首先概述这些技术及其在制造先进组织/器官模型方面的能力。然后，我们分析它们在应对一系列当前生物医学挑战方面的影响。最后，我们通过将这些技术与人工智能和大数据分析等其他前沿研究领域相结合，推测它们未来的发展。
