Zhu Yuhang, Liu Wanguo, Liu Kangding, Gao Ying, Wang Sibo
Department of Orthopedics China-Japan Union Hospital of Jilin University Changchun China.
Department of Neurology, Center for Neuroscience The First Hospital of Jilin University Changchun China.
J Am Heart Assoc. 2025 Apr;14(7):e039135. doi: 10.1161/JAHA.124.039135. Epub 2025 Mar 26.
Stroke is a major global cause of death and disability, with high body mass index (HBMI) as a key modifiable risk factor. Understanding HBMI-attributable stroke burden is crucial for effective prevention.
Using Global Burden of Disease 2021 data, we analyzed disability-adjusted life years and mortality from stroke and its subtypes (ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage) attributable to HBMI at global, regional, and national levels from 1990 to 2021. We conducted decomposition, frontier, inequality, and predictive analyses to assess epidemiological trends and future projections up to 2035. Despite country-specific variations in disability-adjusted life years and mortality, the global burden of stroke and its subtypes attributable to HBMI has increased from 1990 to 2021. Frontier analysis indicated that countries with higher sociodemographic index were expected to own lower age-standardized rates for stroke and its subtypes attributable to HBMI. Decomposition analysis revealed that population growth and aging were the primary contributors to the rise. Significant cross-country disparities remained, although inequality analysis showed a decline in SDI-related differences over time. The projected annual rise in disability-adjusted life years and mortality from 2021 to 2035 suggested ongoing significant challenges in stroke control and management in the coming decades.
The global health challenge posed by the increasing burden of stroke and its subtypes attributable to HBMI remains significant, especially in low- and middle-sociodemographic index regions. Targeted lifestyle modifications and policy interventions are crucial for reducing HBMI and mitigating stroke burden, warranting special attention from policymakers in high-burden regions.
中风是全球主要的死亡和残疾原因，高体重指数（HBMI）是一个关键的可改变风险因素。了解归因于HBMI的中风负担对于有效预防至关重要。
利用《2021年全球疾病负担》数据，我们分析了1990年至2021年全球、区域和国家层面归因于HBMI的中风及其亚型（缺血性中风、脑出血、蛛网膜下腔出血）的伤残调整生命年和死亡率。我们进行了分解、前沿、不平等和预测分析，以评估直至2035年的流行病学趋势和未来预测。尽管不同国家在伤残调整生命年和死亡率方面存在差异，但1990年至2021年期间，全球归因于HBMI的中风及其亚型的负担有所增加。前沿分析表明，社会人口指数较高的国家，其归因于HBMI的中风及其亚型的年龄标准化率预计较低。分解分析显示，人口增长和老龄化是负担上升的主要原因。尽管不平等分析表明，与社会人口指数相关的差异随时间推移有所下降，但国家间仍存在显著差距。2021年至2035年期间，预计伤残调整生命年和死亡率将逐年上升，这表明未来几十年中风控制和管理仍面临重大挑战。
归因于HBMI的中风及其亚型负担不断增加所带来的全球健康挑战仍然严峻，尤其是在社会人口指数较低和中等的地区。有针对性的生活方式改变和政策干预对于降低HBMI和减轻中风负担至关重要，高负担地区的政策制定者应予以特别关注。
