Bergdoll M S, Reiser R F, Crass B A, Robbins R N, Thompson N E
Postgrad Med J. 1985;61 Suppl 1:35-8.
From isolates of Staphylococcus aureus derived from patients suffering from toxic shock syndrome a toxin was identified by tests in monkeys and was found to be distinct from the enterotoxin responsible for staphylococcal food poisoning. When purified, this TSS toxin (TSST-1) was characterised and used to generate antibodies in rabbits. Only a small proportion of routine staphylococcal isolates produce TSST-1, though it is clear that this toxin has existed for some years. At the same time, TSST-1 producing staphylococci have been isolated in every continent, yet very few cases of toxic shock syndrome have been recognised in developing countries. Using the purified TSST-1, human sera have been examined for the presence of antibodies. Patients with the disease had either no antibodies, or low titres.
从患有中毒性休克综合征患者身上分离出的金黄色葡萄球菌菌株中，通过在猴子身上进行的试验鉴定出一种毒素，发现它与引起葡萄球菌食物中毒的肠毒素不同。纯化后的这种中毒性休克综合征毒素（TSST-1）经过了特性鉴定，并用于在兔子体内产生抗体。虽然很明显这种毒素已经存在数年，但只有一小部分常规葡萄球菌分离株能产生TSST-1。与此同时，各大洲都分离出了产生TSST-1的葡萄球菌，但发展中国家确诊的中毒性休克综合征病例却很少。利用纯化后的TSST-1，对人血清中的抗体进行了检测。患有该病的患者要么没有抗体，要么抗体滴度很低。
