Dési I, Dobronyi I, Varga L
Ecotoxicol Environ Saf. 1986 Dec;12(3):220-32. doi: 10.1016/0147-6513(86)90014-x.
The toxicologic properties of the synthetic pyrethroid insecticide cypermethrin have been studied in animal experiments. In the course of acute and subchronic experiments performed by the administration of 1/2 and 1/40, 1/20, and 1/10 proportions of the oral LD50 value, no considerable changes were found in the general toxicologic tests. The compound known to affect the central nervous system, however, induced only a mild enhancement of the central excitation level shown by the EEG investigations in the doses applied. In the immunotoxicologic studies an early and dose-dependent suppression was induced as a result of humoral immune response of rabbits immunised by S. typhi following the administration of cypermethrin. The cell-mediated immune response was also decreased. In rats the immune response determined by anti-sheep erythrocyte and antiovalbumin titer as well as by autologous rosette formation of spleen lymphocytes was hindered. The earliest detectable group of symptoms indicating the effect of a mild cypermethrin exposure is the appearance of the positivity of the immunotoxicologic tests. On the basis of the experimental findings the sensitive immunotoxicologic tests have been regarded as of great importance in the series of toxicologic methods.
已在动物实验中对合成拟除虫菊酯杀虫剂氯氰菊酯的毒理学特性进行了研究。在通过给予口服半数致死剂量值的1/2、1/40、1/20和1/10比例进行的急性和亚慢性实验过程中，一般毒理学测试未发现明显变化。然而，已知该化合物会影响中枢神经系统，在所应用的剂量下，脑电图研究显示其仅引起中枢兴奋水平的轻度增强。在免疫毒理学研究中，氯氰菊酯给药后，用伤寒沙门氏菌免疫的兔子的体液免疫反应导致了早期且剂量依赖性的抑制。细胞介导的免疫反应也有所降低。在大鼠中，由抗绵羊红细胞和抗卵清蛋白效价以及脾淋巴细胞的自体玫瑰花结形成所确定的免疫反应受到阻碍。表明轻度氯氰菊酯暴露影响的最早可检测到的症状组是免疫毒理学测试呈阳性。根据实验结果，敏感的免疫毒理学测试在一系列毒理学方法中被视为非常重要。
