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糖蛋白 2 作为肠道的守门员，维持黏膜炎症与免疫之间的平衡。

Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

机构信息

Department of Innovative Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

Chiba University Futuristic Mucosal Vaccine Research and Development Synergy Institute (cSIMVa), Chiba, Japan.

出版信息

Semin Immunopathol. 2024 Jan;45(4-6):493-507. doi: 10.1007/s00281-023-00999-z. Epub 2024 Jan 3.

DOI:10.1007/s00281-023-00999-z
PMID:38170255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11136868/
Abstract

Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.

摘要

糖蛋白 2（GP2）是一种广泛分布于消化道的蛋白质，有助于维持黏膜屏障、免疫平衡和抗原特异性免疫反应，同时与炎症性肠病（IBD）的发病机制有关。本综述揭示了 GP2 在胃肠道中的广泛分布及其与免疫系统的复杂相互作用。此外，还强调了 GP2 自身抗体在诊断和分类 IBD 中的重要性，以及调节 GP2 来调节免疫和维持黏膜平衡的有前途的治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324f/11136868/2dba72bcedd3/281_2023_999_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324f/11136868/c208a514e4b4/281_2023_999_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324f/11136868/2dba72bcedd3/281_2023_999_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324f/11136868/c208a514e4b4/281_2023_999_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/324f/11136868/2dba72bcedd3/281_2023_999_Fig2_HTML.jpg

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Human glycoprotein-2 expressed in Brunner glands - A putative autoimmune target and link between Crohn's and coeliac disease.人 Brunners 腺糖蛋白-2 - 一种潜在的自身免疫性靶标及克罗恩病和乳糜泻之间的联系。
Clin Immunol. 2023 Feb;247:109214. doi: 10.1016/j.clim.2022.109214. Epub 2023 Jan 4.
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Int J Mol Sci. 2025 Mar 28;26(7):3112. doi: 10.3390/ijms26073112.
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