从正常新生儿皮肤成纤维细胞中生成三个同基因的人诱导多能干细胞系。
Generation of three isogenic human induced pluripotent stem cell lines from normal neonate skin fibroblasts.
机构信息
Institute of Biomedicine and Western Finland Cancer Center (FICAN West), University of Turku, Turku FI-20520, Finland.
Institute of Biomedicine and Western Finland Cancer Center (FICAN West), University of Turku, Turku FI-20520, Finland.
出版信息
Stem Cell Res. 2024 Feb;74:103301. doi: 10.1016/j.scr.2023.103301. Epub 2023 Dec 30.
Characterized human induced pluripotent stem cell lines are important for basic research. Here, we report the establishment of three isogenic human induced pluripotent stem cell (hiPSC) lines generated from normal neonate male skin fibroblasts. Pluripotency was induced using the integration free Sendai virus reprogramming method. The pluripotency, identity, quality, and safety of the lines were confirmed to establish characterized human induced pluripotent stem cell lines to be used as normal control cell lines in future studies.
人诱导多能干细胞系的特征对于基础研究很重要。在这里，我们报告了从正常新生儿男性皮肤成纤维细胞中建立的三个同基因人诱导多能干细胞（hiPSC）系。使用无整合的 Sendai 病毒重编程方法诱导多能性。这些细胞系的多能性、身份、质量和安全性得到了确认，建立了特征明确的人诱导多能干细胞系，可作为未来研究中的正常对照细胞系。
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