Prakash U, Dey P K
Indian J Physiol Pharmacol. 1980 Jul-Sep;24(3):205-15.
The present findings demonstrate that seasonal air temperature does not only influence the basal core temperature of rats, but also modifies the physiological/pharmacological actions of drugs. Thus, at low ambient temperature, intracerebroventricular on intraperitoneal administration of morphine produces mainly hypothermia followed by a secondary rise in rectal temperature. On the other hand, at high ambient temperature, the drug produces hyperthermia only. The hypothermic response at low ambient temperature is abolished by pretreatment of rats with 6-hydroxydopamine but not with phenoxybenzamine administration. This suggests that catecholamine pathway in the central nervous system is involved in morphine induced hypothermic response. Further, the role of cholinergic neurons in such response is also indicated.
目前的研究结果表明，季节性气温不仅会影响大鼠的基础核心体温，还会改变药物的生理/药理作用。因此，在低环境温度下，脑室内或腹腔内注射吗啡主要会导致体温过低，随后直肠温度会出现二次升高。另一方面，在高环境温度下，该药物只会导致体温过高。用6-羟基多巴胺预处理大鼠可消除低环境温度下的低温反应，但用酚苄明处理则不能。这表明中枢神经系统中的儿茶酚胺途径参与了吗啡诱导的低温反应。此外，胆碱能神经元在这种反应中的作用也得到了体现。
