Cornwell G G, Sletten K, Olofsson B O, Johansson B, Westermark P
J Clin Pathol. 1987 Feb;40(2):226-31. doi: 10.1136/jcp.40.2.226.
In recent years prealbumin has been shown to be a major component of two forms of systemic amyloid, senile systemic amyloid (SSA), and familial amyloidotic polyneuropathy (FAP). Despite the fact that the amyloid fibril proteins associated with these two forms of amyloid, designated ASc1 and AF, respectively, share many similarities the clinical features of the two diseases are remarkably different. To understand better this paradox the clinical, histochemical, immunological and biochemical features of SSA and FAP were reviewed.
近年来,前白蛋白已被证明是两种系统性淀粉样变性的主要成分,即老年系统性淀粉样变性(SSA)和家族性淀粉样多神经病(FAP)。尽管与这两种淀粉样变性相关的淀粉样纤维蛋白(分别命名为ASc1和AF)有许多相似之处,但这两种疾病的临床特征却显著不同。为了更好地理解这一矛盾现象,我们回顾了SSA和FAP的临床、组织化学、免疫学和生物化学特征。