Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology.
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University.
Proc Jpn Acad Ser B Phys Biol Sci. 2024;100(1):32-56. doi: 10.2183/pjab.100.004.
Significant progress has been achieved in the field of solid-state biosensors over the past 50 years. Various sensing devices with high-density integration and flexible configuration, as well as new applications for clinical diagnosis and healthcare, have been developed using blood, serum, and other body fluids such as sweat, tears, and saliva. A high-density array of ion-sensitive field effect transistors was developed by exploiting the advantages of advanced semiconductor technologies and commercialized in combination with an enzymatic primer extension reaction as a DNA sequencer in 2011. Different types of materials such as inorganic materials, metals, polymers, and biomolecules are mixed together on the surface of the gate while maintaining their own functions; therefore, compatibility among different materials has to be optimized so that the best detection performance of solid-state biosensors, including stability and reliability, is achieved as designed. Solid-state biosensors are suitable for the rapid, cost-effective, and noninvasive identification of biomarkers at various timepoints over the course of a disease.
在过去的 50 年中，固态生物传感器领域取得了重大进展。利用先进的半导体技术优势，开发出了具有高密度集成和灵活配置的各种传感设备，以及用于临床诊断和医疗保健的新应用，这些应用使用了血液、血清和其他体液，如汗液、眼泪和唾液。2011 年，高密度离子敏感场效应晶体管阵列被开发出来，并与酶引物延伸反应相结合，商业化作为 DNA 测序仪。不同类型的材料，如无机材料、金属、聚合物和生物分子，在栅极表面混合在一起，同时保持各自的功能；因此，必须优化不同材料之间的兼容性，以实现固态生物传感器的最佳检测性能，包括稳定性和可靠性，以达到设计要求。固态生物传感器适用于在疾病过程中的各个时间点快速、经济高效、非侵入性地识别生物标志物。
