Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Department of Gastroenterology, Zigong First People's Hospital, Zigong, Sichuan, China.
J Transl Med. 2024 Jan 10;22(1):41. doi: 10.1186/s12967-023-04842-9.
As more is learned about lactate, it acts as both a product and a substrate and functions as a shuttle system between different cell populations to provide the energy for sustaining tumor growth and proliferation. Recent discoveries of protein lactylation modification mediated by lactate play an increasingly significant role in human health (e.g., neural and osteogenic differentiation and maturation) and diseases (e.g., tumors, fibrosis and inflammation, etc.). These views are critically significant and first described in detail in this review. Hence, here, we focused on a new target, protein lactylation, which may be a "double-edged sword" of human health and diseases. The main purpose of this review was to describe how protein lactylation acts in multiple physiological and pathological processes and their potential mechanisms through an in-depth summary of preclinical in vitro and in vivo studies. Our work aims to provide new ideas for treating different diseases and accelerate translation from bench to bedside.
随着对乳酸的了解不断深入，它既可以作为产物，也可以作为底物，并作为不同细胞群体之间的穿梭系统，为维持肿瘤生长和增殖提供能量。最近发现的由乳酸介导的蛋白质乳酰化修饰在人类健康（例如神经和成骨分化和成熟）和疾病（例如肿瘤、纤维化和炎症等）中发挥着越来越重要的作用。这些观点非常重要，并且在本综述中首次进行了详细描述。因此，在这里，我们专注于一个新的目标，即蛋白质乳酰化，它可能是人类健康和疾病的“双刃剑”。本综述的主要目的是通过深入总结临床前的体外和体内研究，描述蛋白质乳酰化在多种生理和病理过程中的作用及其潜在机制。我们的工作旨在为治疗不同疾病提供新的思路，并加速从实验室到临床的转化。
