Li Zongjie, Jin Yinyin, Wang Xingyu, Xu Liudong, Teng Liyan, Fu Kang, Li Baoling, Li Yulu, Huang Ying, Ma Ning, Cui Feng, Chai Tingting
College of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.
Collaborative Innovation Center of Green Pesticide, Zhejiang A & F University, Hangzhou 311300, China.
Foods. 2023 Dec 21;13(1):31. doi: 10.3390/foods13010031.
Intensive aquaculture combatting the decline of large yellow croaker populations can trigger bacterial outbreaks, resulting in extensive antibiotic use. In this study, we screened 5 aquaculture sites in the coastal areas of Zhejiang and identified 17 antibiotics in large yellow croakers using UPLC-MS/MS. The distribution and occurrence of antibiotic pollutants were different in the different tissues of large yellow croakers, being primarily dominated by quinolones. Relatively higher average residue levels of enrofloxacin and ciprofloxacin were detected in the inedible parts, specifically the gills (37.29 μg/kg). Meanwhile, relatively high average residue levels of enrofloxacin and ciprofloxacin were also found in the edible parts, particularly in the muscle (23.18 μg/kg). We observed that the residue levels detected in the swim bladder exceeded the prescribed limit for fish muscle, but there is currently no specific regulatory limit established for this particular tissue. Despite the HI values of enrofloxacin and ciprofloxacin being below 0.01, the health risks should not be disregarded. The findings of this research provide significant practical implications for assessing antibiotic contamination and enhancing the risk management of coastal regions.
集约化水产养殖在应对大黄鱼种群数量下降时可能引发细菌爆发，导致抗生素大量使用。在本研究中，我们对浙江沿海的5个水产养殖场所进行了筛查，并使用超高效液相色谱-串联质谱法（UPLC-MS/MS）在大黄鱼体内鉴定出17种抗生素。抗生素污染物在大黄鱼不同组织中的分布和存在情况各不相同，主要以喹诺酮类为主。在不可食用部分，特别是鳃（37.29μg/kg）中，检测到恩诺沙星和环丙沙星的平均残留水平相对较高。同时，在可食用部分，尤其是肌肉（23.18μg/kg）中也发现了相对较高的恩诺沙星和环丙沙星平均残留水平。我们观察到，在鱼鳔中检测到的残留水平超过了鱼类肌肉的规定限量，但目前针对该特定组织尚未制定具体的监管限量。尽管恩诺沙星和环丙沙星的危害商数低于0.01，但健康风险仍不容忽视。本研究结果为评估抗生素污染和加强沿海地区风险管理提供了重要的实际意义。
