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轻微身体异常与学习障碍:产前因素是什么?

Minor physical anomalies and learning disability: what is the prenatal component?

作者信息

Marino R V, Scholl T O, Karp R J, Yanoff J M, Hetherington J

出版信息

J Natl Med Assoc. 1987 Jan;79(1):37-9.

PMID:3820331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2571311/
Abstract

The authors performed a case-control study of 60 school children who were examined for a constellation of anomalies suggestive of fetal alcohol exposure. Nonretarded learning disabled children were 7.25 times (95%, confidence interval, 1.05 to 50.0) more likely than controls to have signs consistent with alcohol exposure in fetal life. These data suggest an expanded spectrum of fetal alcohol effects. Early recognition of minor physical anomalies could result in prompt evaluation and treatment of these children.

摘要

作者对60名学童进行了一项病例对照研究,这些学童接受了一系列提示胎儿酒精暴露的异常检查。与对照组相比,无智力发育迟缓的学习障碍儿童出现与胎儿期酒精暴露相符体征的可能性要高7.25倍(95%置信区间为1.05至50.0)。这些数据表明胎儿酒精影响的范围有所扩大。早期识别轻微身体异常可能会促使对这些儿童进行及时评估和治疗。

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本文引用的文献

1
Behavior and learning difficulties in children of normal intelligence born to alcoholic mothers.酗酒母亲所生智力正常儿童的行为和学习困难
J Pediatr. 1980 Jun;96(6):978-82. doi: 10.1016/s0022-3476(80)80621-4.
2
Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester.酒精、吸烟与孕早期和孕中期自然流产的发生率
Lancet. 1980 Jul 26;2(8187):173-6. doi: 10.1016/s0140-6736(80)90061-6.
3
Head circumference from birth to eighteen years. Practical composite international and interracial graphs.从出生到18岁的头围。实用的综合国际和跨种族图表。
Pediatrics. 1968 Jan;41(1):106-14.
4
The foetal alcohol syndrome.胎儿酒精综合征
Acta Paediatr Belg. 1977 Apr-Jun;30(2):117-21.
5
Adverse effects on offspring of maternal alcohol abuse during pregnancy.孕期母亲酗酒对后代的不良影响。
N Engl J Med. 1977 Sep 8;297(10):528-30. doi: 10.1056/NEJM197709082971003.
6
The effects of moderate alcohol consumption during pregnancy on fetal growth and morphogenesis.孕期适度饮酒对胎儿生长和形态发生的影响。
J Pediatr. 1978 Mar;92(3):457-60. doi: 10.1016/s0022-3476(78)80449-1.
7
The fetal alcohol syndrome.胎儿酒精综合征
N Engl J Med. 1978 May 11;298(19):1063-7. doi: 10.1056/NEJM197805112981906.