轻微身体异常与学习障碍：产前因素是什么？
Minor physical anomalies and learning disability: what is the prenatal component?
作者信息
Marino R V, Scholl T O, Karp R J, Yanoff J M, Hetherington J
出版信息
J Natl Med Assoc. 1987 Jan;79(1):37-9.
Abstract
The authors performed a case-control study of 60 school children who were examined for a constellation of anomalies suggestive of fetal alcohol exposure. Nonretarded learning disabled children were 7.25 times (95%, confidence interval, 1.05 to 50.0) more likely than controls to have signs consistent with alcohol exposure in fetal life. These data suggest an expanded spectrum of fetal alcohol effects. Early recognition of minor physical anomalies could result in prompt evaluation and treatment of these children.
摘要
作者对60名学童进行了一项病例对照研究，这些学童接受了一系列提示胎儿酒精暴露的异常检查。与对照组相比，无智力发育迟缓的学习障碍儿童出现与胎儿期酒精暴露相符体征的可能性要高7.25倍（95%置信区间为1.05至50.0）。这些数据表明胎儿酒精影响的范围有所扩大。早期识别轻微身体异常可能会促使对这些儿童进行及时评估和治疗。
相似文献
1
Minor physical anomalies and learning disability: what is the prenatal component?轻微身体异常与学习障碍：产前因素是什么？
J Natl Med Assoc. 1987 Jan;79(1):37-9.
2
Associations between Prenatal Exposure to Black Carbon and Memory Domains in Urban Children: Modification by Sex and Prenatal Stress.城市儿童产前接触黑碳与记忆领域之间的关联：性别和产前压力的影响
PLoS One. 2015 Nov 6;10(11):e0142492. doi: 10.1371/journal.pone.0142492. eCollection 2015.
3
An investigation of prenatal cannabis exposure and minor physical anomalies in a low risk population.低风险人群中产前大麻暴露与轻微身体异常的调查。
Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):345-50.
4
Fetal alcohol spectrum disorders in Finland: clinical delineation of 77 older children and adolescents.芬兰的胎儿酒精谱系障碍：77名大龄儿童和青少年的临床描述
Am J Med Genet A. 2006 Jan 15;140(2):137-43. doi: 10.1002/ajmg.a.31037.
5
Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes.描述酒精相关神经发育障碍：产前酒精暴露与各种后果。
Alcohol Clin Exp Res. 2020 Jun;44(6):1245-1260. doi: 10.1111/acer.14325. Epub 2020 May 20.
6
Fate analysis of adult hippocampal progenitors in a murine model of fetal alcohol spectrum disorder (FASD).在胎儿酒精谱系障碍（FASD）的小鼠模型中分析成年海马祖细胞的命运。
PLoS One. 2013 Sep 11;8(9):e73788. doi: 10.1371/journal.pone.0073788. eCollection 2013.
7
Light drinking in pregnancy and mid-childhood mental health and learning outcomes.孕期轻饮酒与儿童中期心理健康和学习成果。
Arch Dis Child. 2013 Feb;98(2):107-11. doi: 10.1136/archdischild-2012-302436.
8
Prenatal alcohol exposure and childhood behavior at age 6 to 7 years: I. dose-response effect.产前酒精暴露与6至7岁儿童行为：I.剂量反应效应
Pediatrics. 2001 Aug;108(2):E34. doi: 10.1542/peds.108.2.e34.
9
Effects of prenatal alcohol exposure at school age. I. Physical and cognitive development.学龄期产前酒精暴露的影响。I. 身体和认知发展。
Neurotoxicol Teratol. 1991 Jul-Aug;13(4):357-67. doi: 10.1016/0892-0362(91)90084-a.
10
Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration.补充胆碱可减轻大鼠因新生儿期暴露于酒精而导致的学习缺陷：不同胆碱给药时间的影响。
Brain Res. 2008 Oct 27;1237:91-100. doi: 10.1016/j.brainres.2008.08.048. Epub 2008 Aug 28.
本文引用的文献
1
Behavior and learning difficulties in children of normal intelligence born to alcoholic mothers.酗酒母亲所生智力正常儿童的行为和学习困难
J Pediatr. 1980 Jun;96(6):978-82. doi: 10.1016/s0022-3476(80)80621-4.
2
Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester.酒精、吸烟与孕早期和孕中期自然流产的发生率
Lancet. 1980 Jul 26;2(8187):173-6. doi: 10.1016/s0140-6736(80)90061-6.
3
Head circumference from birth to eighteen years. Practical composite international and interracial graphs.从出生到18岁的头围。实用的综合国际和跨种族图表。
Pediatrics. 1968 Jan;41(1):106-14.
4
The foetal alcohol syndrome.胎儿酒精综合征
Acta Paediatr Belg. 1977 Apr-Jun;30(2):117-21.
5
Adverse effects on offspring of maternal alcohol abuse during pregnancy.孕期母亲酗酒对后代的不良影响。
N Engl J Med. 1977 Sep 8;297(10):528-30. doi: 10.1056/NEJM197709082971003.
6
The effects of moderate alcohol consumption during pregnancy on fetal growth and morphogenesis.孕期适度饮酒对胎儿生长和形态发生的影响。
J Pediatr. 1978 Mar;92(3):457-60. doi: 10.1016/s0022-3476(78)80449-1.
7
The fetal alcohol syndrome.胎儿酒精综合征
N Engl J Med. 1978 May 11;298(19):1063-7. doi: 10.1056/NEJM197805112981906.
Zotero 插件