Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, Qatar.
Biomedical Sciences Department, College of Health Sciences, Qatar University, Doha P.O. Box 2713, Qatar.
Int J Mol Sci. 2023 Dec 22;25(1):194. doi: 10.3390/ijms25010194.
The increasing popularity of electronic cigarettes (e-cigarettes) as an alternative to conventional tobacco products has raised concerns regarding their potential adverse effects. The cardiovascular system undergoes intricate processes forming the heart and blood vessels during fetal development. However, the precise impact of e-cigarette smoke and aerosols on these delicate developmental processes remains elusive. Previous studies have revealed changes in gene expression patterns, disruptions in cellular signaling pathways, and increased oxidative stress resulting from e-cigarette exposure. These findings indicate the potential for e-cigarettes to cause developmental and cardiovascular harm. This comprehensive review article discusses various aspects of electronic cigarette use, emphasizing the relevance of cardiovascular studies in Zebrafish for understanding the risks to human health. It also highlights novel experimental approaches and technologies while addressing their inherent challenges and limitations.
随着电子烟作为传统烟草产品替代品的日益普及，人们对其潜在的不良影响产生了担忧。心血管系统在胎儿发育过程中经历了复杂的形成心脏和血管的过程。然而，电子烟烟雾和气雾剂对这些微妙的发育过程的确切影响仍难以捉摸。先前的研究表明，电子烟暴露会导致基因表达模式改变、细胞信号通路中断以及氧化应激增加。这些发现表明电子烟有可能造成发育和心血管损伤。本文全面综述了电子烟的使用情况，强调了在斑马鱼中进行心血管研究对了解其对人类健康的风险的相关性。同时还介绍了新的实验方法和技术，并讨论了它们所固有的挑战和局限性。
