Soares Beatriz Xavier, Miranda Cláudia C, Fernandes Tiago G
Department of Bioengineering and iBB - Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Associate Laboratory i4HB - Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Comput Struct Biotechnol J. 2023 Jun 7;21:3272-3279. doi: 10.1016/j.csbj.2023.06.005. eCollection 2023.
Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the complex interactions between developing organisms, the environment, and toxic agents. This approach would result in a holistic understanding of the effects of toxic agents on organisms, by considering the interactions between different biological systems and the impacts of toxicants on those interactions. It would be useful in identifying key biological pathways and mechanisms affected by toxic agents, as well as in the development of predictive models to assess potential risks of exposure to toxicants during development. In this review, we discuss the relevance of systems bioengineering to the field of developmental toxicity and provide up-to-date examples that illustrate the use of engineering principles for this application.
发育毒理学是研究化学和物理因素对发育中的生物体影响的学科领域。通过运用系统生物学和生物工程学原理，一种系统生物工程方法可用于研究发育中的生物体、环境和有毒物质之间的复杂相互作用。这种方法将通过考虑不同生物系统之间的相互作用以及有毒物质对这些相互作用的影响，全面理解有毒物质对生物体的影响。它有助于识别受有毒物质影响的关键生物途径和机制，以及开发预测模型以评估发育过程中接触有毒物质的潜在风险。在本综述中，我们讨论系统生物工程与发育毒性领域的相关性，并提供最新实例来说明工程原理在该应用中的使用情况。
