Department of Orthopaedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Clin Oral Implants Res. 2020 Jul;31(7):655-668. doi: 10.1111/clr.13602. Epub 2020 Apr 21.
The objective of the study was to evaluate and compare the effect of different drugs such as simvastatin, alendronate, and tibolone for titanium implant osseointegration enhancement.
Eighty female albino Wistar rats were equally divided into five groups: Group I (ovariectomy), Group II (sham ovariectomy), Group III (alendronate + ovariectomy), Group IV (simvastatin + ovariectomy), and Group V (tibolone + ovariectomy). Three months after ovariectomy, we performed bilateral titanium intramedullary nailing in all groups, followed by oral administration of alendronate, simvastatin, or tibolone for 12 weeks. Examinations included micro-CT, mechanical pull-out test, histology, and bone serum markers.
Peri-implant micro-CT analysis showed a significantly higher overall bone tissue in tibolone compared to the ovariectomy group, while no significant difference was found between the treatment groups. Sham ovariectomy, alendronate, and tibolone groups had a higher body mass density compared to ovariectomy and simvastatin groups. All treatment groups had a greater thickness of the peri-implant compact bone layer compared to ovariectomy group, but the results were not statistically significant. Tibolone presented the highest values in pull-out test, but alendronate showed more consistently positive results compared to other groups. Osteocalcin had in the tibolone group almost three times the value in the ovariectomy group, but the results were not statistically significant.
The hypothesis that alendronate, simvastatin, and tibolone enhance the osseointegration process of intramedullary titanium implants in ovariectomized rats has been accepted, while tibolone could offer the best results.
本研究旨在评估和比较不同药物（如辛伐他汀、阿仑膦酸钠和替勃龙）对钛种植体骨整合增强的效果。
将 80 只雌性白化 Wistar 大鼠等分为五组：I 组（卵巢切除术）、II 组（假手术卵巢切除术）、III 组（阿仑膦酸钠+卵巢切除术）、IV 组（辛伐他汀+卵巢切除术）和 V 组（替勃龙+卵巢切除术）。卵巢切除 3 个月后，所有组均进行双侧钛髓内钉植入，随后口服阿仑膦酸钠、辛伐他汀或替勃龙 12 周。检查包括微 CT、机械拔出试验、组织学和骨血清标志物。
种植体周围微 CT 分析显示，替勃龙组的总体骨组织明显高于卵巢切除术组，而治疗组之间无显著差异。假手术卵巢切除术、阿仑膦酸钠和替勃龙组的体质量密度高于卵巢切除术和辛伐他汀组。所有治疗组的种植体周围密质骨层厚度均大于卵巢切除术组，但结果无统计学意义。替勃龙组拔出试验的数值最高，但阿仑膦酸钠组的结果比其他组更一致为阳性。在替勃龙组中，骨钙素的数值几乎是卵巢切除术组的三倍，但结果无统计学意义。
接受了阿仑膦酸钠、辛伐他汀和替勃龙可增强去卵巢大鼠髓内钛种植体骨整合过程的假设，而替勃龙可能提供最佳结果。
