Department of Clinical and Experimental Sciences, Unit of Infectious and Tropical Diseases, University of Brescia-ASST Spedali Civili, Brescia, Italy.
Department of Clinical and Experimental Sciences, Section of Dermatology, University of Brescia, Brescia, 25123, Italy.
BMC Infect Dis. 2024 Jan 17;24(1):95. doi: 10.1186/s12879-024-08998-7.
Orf virus (ORFV) is the pathogen responsible for Orf, a zoonotic viral infection that can be spread to humans from sheep and goats. Here, we present a case of human Orf complicated by an immune-related reaction, to raise awareness of this under-recognized disease avoiding unnecessary investigations and overtreatment.
A 51-year-old woman with no previous medical history presented with a one-week history of three asymptomatic swelling nodules with a grey necrotic center and red outer halo on her index finger. At physical examination there was also a pruritic papulovesicular eruption on her hands and feet. She reported a recent contact with a goat which had a similar nodular lesion in its mouth. A biopsy of the lesions was performed and a diagnosis of Orf complicated by widespread erythema multiforme was made based on the clinical and histopathological features. The lesions spontaneously resolved within the next 2 weeks.
Orf is not very prevalent in our region, so we performed a biopsy of the lesion to guide us toward a diagnosis. However, we should remember that the diagnosis of ecthyma relies on clinical evaluation and epidemiological criteria.
口疮病毒(ORFV)是引起口疮的病原体,这是一种可从绵羊和山羊传播给人类的人畜共患病毒性感染。在此,我们报告了一例人类口疮病例,该病例并发免疫相关反应,旨在提高对这种认识不足的疾病的认识,避免不必要的检查和过度治疗。
一名 51 岁女性,无既往病史,因食指上有三个无症状的肿胀结节,中心有灰色坏死,周围有红色晕圈,病史达一周。体格检查时,她的手和脚还出现了瘙痒性丘疹水疱疹。她报告说最近接触过一只山羊,其口腔也有类似的结节性病变。对病变进行了活检,根据临床和组织病理学特征,诊断为口疮并发广泛多形红斑。在接下来的 2 周内,病变自行消退。
口疮在我们地区并不常见,因此我们对病变进行了活检以指导诊断。然而,我们应该记住,疱疹样皮炎的诊断依赖于临床评估和流行病学标准。