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从脓液中分离出的耐碳青霉烯类鼻疽伯克霍尔德菌中blaNDM和blaOXA - 48基因的共存:一种罕见现象。

Coexistence of blaNDM and blaOXA-48 Genes in Carbapenem-Resistant Burkholderia pseudomallei Isolated From Pus: A Rare Phenomenon.

作者信息

Verma Gaurav, Singh Nipa, Mohanty Ambika, Patro A Raj Kumar, Pattnaik Dipti

机构信息

Department of Microbiology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

Department of General Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

出版信息

Cureus. 2023 Dec 17;15(12):e50671. doi: 10.7759/cureus.50671. eCollection 2023 Dec.

Abstract

causes melioidosis in both humans as well as animals and is classified as a tier 1 pathogen by the US CDC. Melioidosis is a disease that occurs predominantly in subtropical and tropical regions. It is endemic to northern Australia and parts of Southeast Asia, as well as the Indian subcontinent. Diagnosis can be made through history, clinical examination, imaging, and microbiological studies. We report a case where was isolated froma 41-year-old man who complained of pain in the left hip and the left shoulder and swelling in both lower limbs. Chest X-ray showed bilateral consolidation. USG of the left shoulder and bilateral hips showed a mass in the anterior region of the left upper arm and the lateral region of the left thigh. Pus aspirated from left shoulder grew  on culture and was carbapenem-resistant. The isolate harbored two carbapenemase genes, blaNDM and blaOXA-48,which is a novel finding.

摘要

可导致人类和动物感染类鼻疽,被美国疾病控制与预防中心列为一级病原体。类鼻疽是一种主要发生在亚热带和热带地区的疾病。在澳大利亚北部、东南亚部分地区以及印度次大陆呈地方性流行。可通过病史、临床检查、影像学和微生物学研究进行诊断。我们报告一例病例,从一名41岁男性身上分离出该病菌,该男子主诉左髋部和左肩疼痛以及双下肢肿胀。胸部X光显示双侧实变。左肩和双侧髋部的超声检查显示左上臂前部和左大腿外侧有肿块。从左肩吸出的脓液培养后生长出该病菌,且对碳青霉烯类耐药。分离株携带两种碳青霉烯酶基因,blaNDM和blaOXA - 48,这是一个新发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e178/10790810/2490146ad1cd/cureus-0015-00000050671-i01.jpg

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