State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China.
Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110016, China.
Adv Healthc Mater. 2024 May;13(12):e2303767. doi: 10.1002/adhm.202303767. Epub 2024 Jan 26.
Microrobots have emerged as powerful tools for manipulating particles, cells, and assembling biological tissue structures at the microscale. However, achieving precise and flexible operation of arbitrary-shaped microstructures in 3D space remains a challenge. In this study, three novel operation methods based on bubble microrobots are proposed to enable delicate and multifunctional manipulation of various microstructures. These methods include 3D turnover, fixed-point rotation, and 3D ejection. By harnessing the combined principles of the effect of the heat flow field and surface tension of an optothermally generated bubble, the bubble microrobot can perform tasks such as flipping an SIA humanoid structure, rotating a bird-like structure, and launching a hollow rocket-like structure. The proposed multi-mode operation of bubble microrobots enables diverse attitude adjustments of microstructures with different sizes and shapes in both 2D and 3D spaces. As a demonstration, a biological microenvironment of brain glioblastoma is constructed by the bubble microrobot. The simplicity, versatility, and flexibility of this proposed method hold great promise for applications in micromanipulation, assembly, and tissue engineering.
微机器人已成为在微尺度上操纵粒子、细胞和组装生物组织结构的强大工具。然而，实现任意形状的微结构在 3D 空间中的精确和灵活操作仍然是一个挑战。在这项研究中，提出了三种基于气泡微机器人的新型操作方法，以实现对各种微结构的精细多功能操作。这些方法包括 3D 翻转、定点旋转和 3D 弹射。通过利用热流场和光热生成气泡的表面张力的综合作用原理，气泡微机器人可以执行翻转 SIA 人形结构、旋转鸟状结构和发射空心火箭状结构等任务。所提出的气泡微机器人的多模式操作能够实现不同尺寸和形状的微结构在 2D 和 3D 空间中的多种姿态调整。作为演示，使用气泡微机器人构建了脑胶质母细胞瘤的生物微环境。这种方法的简单性、通用性和灵活性为微操作、组装和组织工程中的应用提供了广阔的前景。
