Department of Respiratory Medicine, Connolly Hospital Blanchardstown, RCSI Hospital Group, Dublin, Ireland.
Ir J Med Sci. 2024 Jun;193(3):1131-1136. doi: 10.1007/s11845-023-03597-y. Epub 2024 Jan 17.
In this study, we aim to describe the demographic, clinical and imaging characteristics, treatment course and subsequent outcomes of the first 116 cases presenting to a tertiary Dublin hospital with COVID-19 infection and to compare whether ethnic minority background was a risk factor for poorer disease outcomes in this cohort. Of 116 cases analysed, 100 (86%) patients presented from the community, 6 (5%) from care homes and 10 (9%) were existing inpatients. Fifty-four (46%) patients identified as being from an ethnic minority group. One hundred fourteen (98%) patients reported two or more symptoms at time of diagnosis with 81 (70%) patients having confirmed radiological findings of COVID-19 infection. Median duration of symptoms prior to hospital presentation was 6 days (IQR 3-10 days). The median age at presentation was 52 years (IQR 43-65). Co-morbidities recorded included hypertension, hyperlipidaemia, type 2 diabetes mellitus, underlying respiratory disease, previous or current malignancy and current smoker. Twenty-six patients (22%) required ICU admission, 20 (76.9%) of these were from all other ethnic groups combined and 6 (10%) from White Irish group. Adjusting for variables of age, ethnicity and gender, all other ethnic groups combined were five times more likely to require ICU admission than White Irish group (Table 5). Patients from all other ethnic groups combined admitted to ICU were significantly younger than patients from White Irish group (OR 50.85 vs 62.83, P = 0.012). Our hospital's catchment area serves a wide-ranging and diverse population with many ethnic minority groups represented. Our data demonstrated that there was a significant overrepresentation of a younger cohort of patients from ethnic minority groups admitted to ICU with COVID-19 infection with less co-morbidities than that of the White Irish group.
在这项研究中,我们旨在描述 116 例首次因 COVID-19 感染而到都柏林一家三级医院就诊的患者的人口统计学、临床和影像学特征、治疗过程和随后的结果,并比较少数族裔背景是否是该队列中疾病结局较差的危险因素。在分析的 116 例病例中,100 例(86%)患者来自社区,6 例(5%)来自护理院,10 例(9%)为现有住院患者。54 例(46%)患者被确定为少数族裔群体。114 例(98%)患者在诊断时报告有两种或两种以上症状,81 例(70%)患者有 COVID-19 感染的影像学确诊结果。从出现症状到入院的中位时间为 6 天(IQR 3-10 天)。入院时的中位年龄为 52 岁(IQR 43-65 岁)。记录的合并症包括高血压、高脂血症、2 型糖尿病、基础呼吸系统疾病、既往或现患恶性肿瘤和当前吸烟者。26 例(22%)需要入住 ICU,其中 20 例(76.9%)来自所有其他族裔群体,6 例(10%)来自白人爱尔兰群体。在调整年龄、族裔和性别等变量后,所有其他族裔群体需要入住 ICU 的可能性是白人爱尔兰群体的五倍(表 5)。所有其他族裔群体中入住 ICU 的患者明显比白人爱尔兰群体年轻(OR 50.85 比 62.83,P=0.012)。我们医院的服务范围广泛,人群多样化,代表了许多少数族裔群体。我们的数据表明,少数族裔群体中 ICU 收治的年轻患者比例显著较高,且合并症少于白人爱尔兰群体。