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非傅里叶生物传热分析在间质激光消融期间的脑组织：多个影响因素的分析。

Non-Fourier Bioheat Transfer Analysis in Brain Tissue During Interstitial Laser Ablation: Analysis of Multiple Influential Factors.

机构信息

Faculty of Sustainable Design Engineering, University of Prince Edward Island, Charlottetown, PE, C1A 4P3, Canada.

Department of Mechanical Engineering, Politecnico di Milano, 20156, Milan, Italy.

出版信息

Ann Biomed Eng. 2024 Apr;52(4):967-981. doi: 10.1007/s10439-023-03433-5. Epub 2024 Jan 18.

DOI:10.1007/s10439-023-03433-5
PMID:38236341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11252202/
Abstract

This work presents the dual-phase lag-based non-Fourier bioheat transfer model of brain tissue subjected to interstitial laser ablation. The finite element method has been utilized to predict the brain tissue's temperature distributions and ablation volumes. A sensitivity analysis has been conducted to quantify the effect of variations in the input laser power, treatment time, laser fiber diameter, laser wavelength, and non-Fourier phase lags. Notably, in this work, the temperature-dependent thermal properties of brain tissue have been considered. The developed model has been validated by comparing the temperature obtained from the numerical and ex vivo brain tissue during interstitial laser ablation. The ex vivo brain model has been further extended to in vivo settings by incorporating the blood perfusion effects. The results of the systematic analysis highlight the importance of considering temperature-dependent thermal properties of the brain tissue, non-Fourier behavior, and microvascular perfusion effects in the computational models for accurate predictions of the treatment outcomes during interstitial laser ablation, thereby minimizing the damage to surrounding healthy tissue. The developed model and parametric analysis reported in this study would assist in a more accurate and precise prediction of the temperature distribution, thus allowing to optimize the thermal dosage during laser therapy in the brain.

摘要

本文提出了一种基于双时滞的非傅里叶生物传热模型，用于研究脑组织在间质激光烧蚀中的情况。采用有限元方法预测脑组织的温度分布和烧蚀体积。通过敏感性分析，量化了输入激光功率、治疗时间、激光光纤直径、激光波长和非傅里叶相位滞后等参数变化的影响。值得注意的是，在这项工作中，考虑了脑组织的温度相关热物性。通过将数值模拟和间质激光烧蚀过程中离体脑组织的温度进行比较，验证了所开发模型的有效性。通过考虑血液灌注效应，进一步将离体脑模型扩展到体内环境。系统分析的结果强调了在计算模型中考虑脑组织的温度相关热物性、非傅里叶行为和微血管灌注效应的重要性，以便在间质激光烧蚀过程中更准确地预测治疗效果，从而最大程度地减少对周围健康组织的损伤。本研究中报告的模型和参数分析将有助于更准确、更精确地预测温度分布，从而优化大脑激光治疗中的热剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/9d56a568af2c/10439_2023_3433_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/36bfc9243daf/10439_2023_3433_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/a070a11989d9/10439_2023_3433_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/333003abd9a1/10439_2023_3433_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/ffc3ad2b8d4c/10439_2023_3433_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/8416528b56ee/10439_2023_3433_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/68c8083a36b3/10439_2023_3433_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/8fc03c875b87/10439_2023_3433_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9de/11252202/2c7c7e9fd469/10439_2023_3433_Fig10_HTML.jpg
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本文引用的文献

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Sci Rep. 2022 Aug 22;12(1):14300. doi: 10.1038/s41598-022-18277-7.
2
Thermophysical and mechanical properties of biological tissues as a function of temperature: a systematic literature review.生物组织的温度相关热物理和力学特性：系统文献回顾。
Int J Hyperthermia. 2022;39(1):297-340. doi: 10.1080/02656736.2022.2028908.
3
Prediction of In Vivo Laser-Induced Thermal Damage with Hyperspectral Imaging Using Deep Learning.
利用深度学习的高光谱成像技术预测体内激光诱导热损伤。
Sensors (Basel). 2021 Oct 19;21(20):6934. doi: 10.3390/s21206934.
4
Endoscopic ultrasound (EUS)-guided cylindrical interstitial laser ablation (CILA) on porcine pancreas.猪胰腺的内镜超声（EUS）引导下圆柱形间质激光消融（CILA）
Biomed Opt Express. 2021 Jun 24;12(7):4423-4437. doi: 10.1364/BOE.427379. eCollection 2021 Jul 1.
5
Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature.测量离体肝脏、大脑和胰腺的热物性随温度的变化。
Sensors (Basel). 2021 Jun 21;21(12):4236. doi: 10.3390/s21124236.
6
Thermomechanical Modeling of Laser Ablation Therapy of Tumors: Sensitivity Analysis and Optimization of Influential Variables.肿瘤激光烧蚀治疗的热力建模：影响变量的灵敏度分析与优化。
IEEE Trans Biomed Eng. 2022 Jan;69(1):302-313. doi: 10.1109/TBME.2021.3092889. Epub 2021 Dec 23.
7
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8
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