Mullins Ewen, Bresson Jean-Louis, Dalmay Tamas, Dewhurst Ian Crawford, Epstein Michelle M, Firbank Leslie George, Guerche Philippe, Hejatko Jan, Moreno Francisco Javier, Naegeli Hanspeter, Nogué Fabien, Rostoks Nils, Sánchez Serrano Jose Juan, Savoini Giovanni, Veromann Eve, Veronesi Fabio, Ardizzone Michele, Camargo Ana M, De Sanctis Giacomo, Federici Silvia, Fernández Antonio, Gennaro Andrea, Gómez Ruiz Jose Ángel, Goumperis Tilemachos, Kagkli Dafni Maria, Lenzi Paolo, Lewandowska Aleksandra, Neri Franco Maria, Papadopoulou Nikoletta, Raffaello Tommaso
EFSA J. 2024 Jan 18;22(1):e8483. doi: 10.2903/j.efsa.2024.8483. eCollection 2024 Jan.
Genetically modified maize DP23211 was developed to confer control of certain coleopteran pests and tolerance to glufosinate-containing herbicide. These properties were achieved by introducing the , , and expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP23211 and its conventional counterpart needs further assessment, except for those in levels of histidine, phenylalanine, magnesium, phosphorus and folic acid in grain, which do not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the IPD072Aa, PAT and PMI proteins and the DvSSJ1 dsRNA and derived siRNAs newly expressed in maize DP23211, and finds no evidence that the genetic modification impacts the overall safety of maize DP23211. In the context of this application, the consumption of food and feed from maize DP23211 does not represent a nutritional concern in humans and animals. Therefore, no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize DP23211 grains into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP23211. The GMO Panel concludes that maize DP23211 is as safe as its conventional counterpart and the tested non-GM reference varieties with respect to potential effects on human and animal health and the environment.
转基因玉米DP23211的开发目的是实现对某些鞘翅目害虫的防治以及对含草铵膦除草剂的耐受性。这些特性是通过导入、、和表达盒实现的。分子特征数据和生物信息学分析未发现需要进行食品/饲料安全性评估的问题。除了籽粒中组氨酸、苯丙氨酸、镁、磷和叶酸含量的差异外,玉米DP23211与其传统对照品种在农艺/表型和成分特征测试中所发现的差异均无需进一步评估,而这些差异不会引发安全性和营养方面的担忧。转基因生物小组未发现与IPD072Aa、PAT和PMI蛋白以及在玉米DP23211中新表达的DvSSJ1双链RNA和衍生的小干扰RNA的毒性和致敏性有关的安全问题,并且没有证据表明基因改造会影响玉米DP23211的整体安全性。在此申请的背景下,食用来自玉米DP23211的食品和饲料对人类和动物不构成营养方面的担忧。因此,认为无需对食品/饲料进行上市后监测。如果有活力的玉米DP23211籽粒意外释放到环境中,这不会引发环境安全问题。上市后环境监测计划和报告间隔与玉米DP23211的预期用途一致。转基因生物小组得出结论,就对人类和动物健康以及环境的潜在影响而言,玉米DP23211与其传统对照品种以及经过测试的非转基因参考品种一样安全。