College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, Shenzhen University, Shenzhen 518060, China.
Mar Drugs. 2023 Dec 28;22(1):22. doi: 10.3390/md22010022.
Crocin is one of the most valuable components of the Chinese medicinal plant and is widely used in the food, cosmetics, and pharmaceutical industries. Traditional planting of is unable to fulfill the increasing demand for crocin in the global market, however, such that researchers have turned their attention to the heterologous production of crocin in a variety of hosts. At present, there are reports of successful heterologous production of crocin in , , microalgae, and plants that do not naturally produce crocin. Of these, the microalga , which produces high levels of -carotene, the substrate for crocin biosynthesis, is worthy of attention. This article describes the biosynthesis of crocin, compares the features of each heterologous host, and clarifies the requirements for efficient production of crocin in microalgae.
藏红花苷是中国药用植物的最有价值成分之一，广泛应用于食品、化妆品和制药行业。然而，传统的种植方式无法满足全球市场对藏红花苷日益增长的需求，因此研究人员将注意力转向了在各种宿主中异源生产藏红花苷。目前，已有报道称在酵母、真菌、微藻和不天然产生藏红花苷的植物中成功异源生产藏红花苷。其中，产生高水平β-胡萝卜素（藏红花苷生物合成的底物）的微藻值得关注。本文描述了藏红花苷的生物合成，比较了每个异源宿主的特点，并阐明了在微藻中高效生产藏红花苷的要求。
