Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114, Wrocław, Poland.
Phage Therapy Unit, Medical Center of the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114, Wrocław, Poland.
J Biomed Sci. 2022 Mar 30;29(1):23. doi: 10.1186/s12929-022-00806-1.
Bacteriophages (phages) may be used as an alternative to antibiotic therapy for combating infections caused by multidrug-resistant bacteria. In the last decades, there have been studies concerning the use of phages and antibiotics separately or in combination both in animal models as well as in humans. The phenomenon of phage-antibiotic synergy, in which antibiotics may induce the production of phages by bacterial hosts has been observed. The potential mechanisms of phage and antibiotic synergy was presented in this paper. Studies of a biofilm model showed that a combination of phages with antibiotics may increase removal of bacteria and sequential treatment, consisting of phage administration followed by an antibiotic, was most effective in eliminating biofilms. In vivo studies predominantly show the phenomenon of phage and antibiotic synergy. A few studies also describe antagonism or indifference between phages and antibiotics. Recent papers regarding the application of phages and antibiotics in patients with severe bacterial infections show the effectiveness of simultaneous treatment with both antimicrobials on the clinical outcome.
噬菌体（phages）可作为对抗抗药性细菌感染的抗生素疗法的替代方案。在过去几十年中，已经有关于单独使用噬菌体和抗生素，以及联合使用噬菌体和抗生素的研究，这些研究分别在动物模型和人类中进行。噬菌体-抗生素协同作用的现象已经被观察到，即在这种现象中，抗生素可能会诱导细菌宿主产生噬菌体。本文介绍了噬菌体和抗生素协同作用的潜在机制。生物膜模型的研究表明，噬菌体和抗生素联合使用可能会增加细菌的清除率，而噬菌体给药后紧接着使用抗生素的序贯治疗在消除生物膜方面最为有效。体内研究主要显示了噬菌体和抗生素协同作用的现象。少数研究还描述了噬菌体和抗生素之间的拮抗作用或不相关。最近关于噬菌体和抗生素在严重细菌感染患者中应用的论文表明，同时使用这两种抗菌药物对临床结果有积极影响。
