Vasilieva Tatiana, Nikolskaya Elena, Vasiliev Michael, Mollaeva Mariia, Chirkina Margarita, Sokol Maria, Yabbarov Nikita, Shikova Tatiana, Abramov Artem, Ugryumov Aleksandr
Joint Institute for High Temperatures of Russian Academy of Sciences, Izhorskaya st. 13 Bd. 2, 125412 Moscow, Russia.
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina st. 4, 119334 Moscow, Russia.
Polymers (Basel). 2024 Jan 6;16(2):172. doi: 10.3390/polym16020172.
The applicability of beam-plasma chemical reactors generating cold hybrid plasma for the production of noncytotoxic polymeric surfaces with high hydrophilicity and good biocompatibility with human fibroblast culture and human red blood cells was studied. Oxygen hybrid plasma was excited by the joint action of a continuous scanning electron beam and a capacity-coupled RF-gas discharge. Experiments showed that hybrid plasma treatment caused polar oxygen-containing functional group formation in the surface layer of poly (ethylene terephthalate) films. No thermal or radiative damage in tested polymer samples was found. The plasma-modified polymers turned out to be noncytotoxic and revealed good biocompatibility with human fibroblasts BJ-5ta as well as lower hemolytic activity than untreated poly (ethylene terephthalate). Experiments also demonstrated that no phenomena caused by the electrostatic charging of polymers occur in hybrid plasma because the electron beam component of hybrid plasma eliminates the item charge when it is treated. The electron beam can effectively control the reaction volume geometry as well as the fluxes of active plasma particles falling on the item surface. This provides new approaches to the production of abruptly structured patterns or smooth gradients of functionalities on a plane and 3D polymeric items of complicated geometry.
研究了产生冷混合等离子体的束-等离子体化学反应器在制备具有高亲水性且与人类成纤维细胞培养物和人类红细胞具有良好生物相容性的无细胞毒性聚合物表面方面的适用性。通过连续扫描电子束和电容耦合射频气体放电的联合作用激发氧混合等离子体。实验表明，混合等离子体处理在聚对苯二甲酸乙二酯薄膜的表面层中形成了含极性氧的官能团。在测试的聚合物样品中未发现热损伤或辐射损伤。结果表明，等离子体改性的聚合物无细胞毒性，并且与人类成纤维细胞BJ-5ta具有良好的生物相容性，并且溶血活性低于未处理的聚对苯二甲酸乙二酯。实验还表明，在混合等离子体中不会出现由聚合物静电充电引起的现象，因为混合等离子体的电子束成分在处理时会消除物体电荷。电子束可以有效地控制反应体积的几何形状以及落在物体表面的活性等离子体粒子的通量。这为在平面和复杂几何形状的3D聚合物物体上产生突然结构化的图案或功能的平滑梯度提供了新方法。
