Demina Tatiana S, Piskarev Mikhail S, Romanova Olga A, Gatin Andrey K, Senatulin Boris R, Skryleva Elena A, Zharikova Tatiana M, Gilman Alla B, Kuznetsov Alexander A, Akopova Tatiana A, Timashev Peter S
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsoyuznaya str., 117393 Moscow, Russia.
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya str., 119991 Moscow, Russia.
Materials (Basel). 2020 Jan 21;13(3):508. doi: 10.3390/ma13030508.
Plasma treatment is one of the most promising tools to control surface properties of materials tailored for biomedical application. Among a variety of processing conditions, such as the nature of the working gas and time of treatment, discharge type is rarely studied, because it is mainly fixed by equipment used. This study aimed to investigate the effect of discharge type (direct vs. alternated current) using air as the working gas on plasma treatment of poly(ethylene terephthalate) films, in terms of their surface chemical structure, morphology and properties using X-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscopy and contact angle measurements. The effect of the observed changes in terms of subsequent chitosan immobilization on plasma-treated films was also evaluated. The ability of native, plasma-treated and chitosan-coated films to support adhesion and growth of mesenchymal stem cells was studied to determine the practicability of this approach for the biomedical application of poly(ethylene terephthalate) films.
等离子体处理是控制为生物医学应用量身定制的材料表面特性最具前景的工具之一。在各种处理条件中，如工作气体的性质和处理时间，放电类型很少被研究，因为它主要由所使用的设备决定。本研究旨在研究以空气作为工作气体时，放电类型（直流与交流）对聚对苯二甲酸乙二酯薄膜等离子体处理的影响，通过X射线光电子能谱、扫描电子显微镜、原子力显微镜和接触角测量来研究其表面化学结构、形态和性能。还评估了观察到的变化对等离子体处理薄膜后续壳聚糖固定化的影响。研究了天然、等离子体处理和壳聚糖涂层薄膜支持间充质干细胞黏附与生长的能力，以确定这种方法在聚对苯二甲酸乙二酯薄膜生物医学应用中的实用性。
